Publikationen von T. Mielke

Shah, C.; Hegde, B. G.; Morén, B.; Behrmann, E.; Mielke, T.; Moenke, G.; Spahn, C. M. T.; Lundmark, R.; Daumke, O.; Langen, R.: Structural insights into membrane interaction and caveolar targeting of dynamin-like EHD2. Structure 22 (3), S. 409 - 420 (2014)

Becker, T.; Armache, J. P.; Jarasch, A.; Anger, A. M.; Villa, E.; Sieber, H.; Motaal, B. A.; Mielke, T.; Berninghausen, O.; Beckmann, R.: Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome. Nature Structural & Molecular Biology 18 (6), S. 715 - 20 (2011)

Bhushan, S.; Hoffmann, T.; Seidelt, B.; Frauenfeld, J.; Mielke, T.; Berninghausen, O.; Wilson, D. N.; Beckmann, R.: SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center. PLoS Biology 9 (1), S. e1000581 (2011)

Budkevich, T.; Giesebrecht, J.; Altman, R. B.; Munro, J. B.; Mielke, T.; Nierhaus, K. H.; Blanchard, S. C.; Spahn, C. M.: Structure and dynamics of the mammalian ribosomal pretranslocation complex. Mol Cell 44 (2), S. 214 - 24 (2011)

Budkevich, T.; Giesebrecht, J.; Altman, R. B.; Munro, J. B.; Mielke, T.; Nierhaus, K. H.; Blanchard, S. C.; Spahn, C. M.: Structure and dynamics of the mammalian ribosomal pretranslocation complex. Molecular Cell 44 (2), S. 214 - 24 (2011)

Czeko, E.; Seizl, M.; Augsberger, C.; Mielke, T.; Cramer, P.: Iwr1 directs RNA polymerase II nuclear import. Molecular Cell 42 (2), S. 261 - 6 (2011)

Frauenfeld, J.; Gumbart, J.; Sluis, E. O.; Funes, S.; Gartmann, M.; Beatrix, B.; Mielke, T.; Berninghausen, O.; Becker, T.; Schulten, K. et al.; Beckmann, R.: Cryo-EM structure of the ribosome-SecYE complex in the membrane environment. Nature Structural & Molecular Biology 18 (5), S. 614 - 21 (2011)

Muhs, M.; Yamamoto, H.; Ismer, J.; Takaku, H.; Nashimoto, M.; Uchiumi, T.; Nakashima, N.; Mielke, T.; Hildebrand, P. W.; Nierhaus, K. H. et al.; Spahn, C. M.: Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit. Nucleic Acids Res 39 (12), S. 5264 - 75 (2011)

Muhs, M.; Yamamoto, H.; Ismer, J.; Takaku, H.; Nashimoto, M.; Uchiumi, T.; Nakashima, N.; Mielke, T.; Hildebrand, P. W.; Nierhaus, K. H. et al.; Spahn, C. M.: Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit. Nucleic Acids Research 39 (12), S. 5264 - 75 (2011)

Ratje, A. H.; Loerke, J.; Mikolajka, A.; Brunner, M.; Hildebrand, P. W.; Starosta, A. L.; Donhofer, A.; Connell, S. R.; Fucini, P.; Mielke, T. et al.; Whitford, P. C.; Onuchic, J. N.; Yu, Y.; Sanbonmatsu, K. Y.; Hartmann, R. K.; Penczek, P. A.; Wilson, D. N.; Spahn, C. M.: Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites. Nature 468 (7324), S. 713 - 716 (2010)

Armache, J. P.; Jarasch, A.; Anger, A. M.; Villa, E.; Becker, T.; Bhushan, S.; Jossinet, F.; Habeck, M.; Dindar, G.; Franckenberg, S. et al.; Marquez, V.; Mielke, T.; Thomm, M.; Berninghausen, O.; Beatrix, B.; Soding, J.; Westhof, E.; Wilson, D. N.; Beckmann, R.: Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution. Preceedings of the National Academy of Sciences USA 107 (46), S. 19748 - 19753 (2010)

Armache, J. P.; Jarasch, A.; Anger, A. M.; Villa, E.; Becker, T.; Bhushan, S.; Jossinet, F.; Habeck, M.; Dindar, G.; Franckenberg, S. et al.; Marquez, V.; Mielke, T.; Thomm, M.; Berninghausen, O.; Beatrix, B.; Soding, J.; Westhof, E.; Wilson, D. N.; Beckmann, R.: Localization of eukaryote-specific ribosomal proteins in a 5.5-A cryo-EM map of the 80S eukaryotic ribosome. Proceedings of the National Academy of Sciences USA 107 (46), S. 19754 - 19759 (2010)

Bhushan, S.; Meyer, H.; Starosta, A. L.; Becker, T.; Mielke, T.; Berninghausen, O.; Sattler, M.; Wilson, D. N.; Beckmann, R.: Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide. (2010)

Gartmann, M.; Blau, M.; Armache, J. P.; Mielke, T.; Topf, M.; Beckmann, R.: Mechanism of eIF6-mediated inhibition of ribosomal subunit joining. The Journal of Biological Chemistry 285 (20), S. 14848 - 14851 (2010)

Bhushan, S.; Gartmann, M.; Halic, M.; Armache, J. P.; Jarasch, A.; Mielke, T.; Berninghausen, O.; Wilson, D. N.; Beckmann, R.: alpha-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel. Nature Structural & Molecular Biology 17 (3), S. 313 - 317 (2010)

Liu, C.; Young, A. L.; Starling-Windhof, A.; Bracher, A.; Saschenbrecker, S.; Rao, B. V.; Rao, K. V.; Berninghausen, O.; Mielke, T.; Hartl, F. U. et al.; Beckmann, R.; Hayer-Hartl, M.: Coupled chaperone action in folding and assembly of hexadecameric Rubisco. Nature 463 (7278), S. 197 - 202 (2010)

Becker, T.; Bhushan, S.; Jarasch, A.; Armache, J.-P.; Soledad, S.; Jossinet, F.; Gumbart, J.; Mielke, T.; Berninghausen, O.; Schulten, K. et al.; Westhof, E.; Gilmore, R.; Mandon, E. C.; Beckmann, R.: Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome. Science 326 (5958), S. 1369 - 1373 (2009)

Jan-Christian Schuette, J.-C.; Murphy, F. V.; Kelley, A. C.; Weir, J. R.; Giesebrecht, J.; Connell, S. R.; Loerke, J.; Mielke, T.; Zhang, W.; Penczek, P. A. et al.; Ramakrishnan, V.; Spahn, C. M. T.: GTPase activation of elongation factor EF-Tu by the ribosome during decoding. The EMBO Journal 28 (6), S. 755 - 765 (2009)

Connell, S. R.; Topf, M.; Qin, Y.; Wilson, D. N.; Mielke, T.; Fucini, P.; Nierhaus, K. H.; Spahn, C. M. T.: A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. Nature Structural & Molecular Biology 15 (9), S. 910 - 915 (2008)

Connell, S. R.; Topf, M.; Qin, Y.; Wilson, D. N.; Mielke, T.; Fucini, P.; Nierhaus, K. H.; Spahn, C. M. T.: A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation. Nature Structural & Molecular Biology 15 (9), S. 910 - 915 (2008)