Tools & Methods

Read-level methylation

https://github.com/sarahet/RLM

Hetzel, S.; Gießelmann, P.; Reinert, K.; Meissner, A.; Kretzmer, H.: RLM: Fast and simplified extraction of Read-Level Methylation metrics from bisulfite sequencing data. Bioinformatics 37 (21), pp. 3934 - 3935 (2021)

Nanopore processing

https://github.com/giesselmann/nanopype

Giesselmann, P.; Hetzel, S.; Müller, F.-J.; Meissner, A.; Kretzmer, H.: Nanopype: A modular and scalable nanopore data processing pipeline. Bioinformatics 2019, btz461 (2019)

DMR calling

https://www.bioinf.uni-leipzig.de/Software/metilene/

Jühling F*, Kretzmer H*, Bernhart SH, Otto C, Stadler PF, Hoffmann S.
 
Metilene: fast and sensitive calling of differentially methylated regions from bisulfite sequencing data.
Genome Research (2016)
Go to Editor View