Lab News
April 11, 2025
Our perspective article on the molecular mechanisms of gene regulation has been published. Here we share our view on how enhancers communicate with target genes through the lens of transcriptional control. Many thanks to Stefan Mundlos for discussions and help. You can read the article here
February 20, 2025
Collaborative work with Achim Tresch’s group at the University of Cologne on a computational tool to quantify RNA half-lives in cells is published. We thank Achim Tresch and Jason Müller for the great collaboration! The article is now online.
July 02, 2024
Our systems-wide study on the dynamics and consequences of RNA isoform changes during human neuronal cell differentiation is featured on the cover of the current issue of Molecular Systems Biology. Many thanks to Geno for the beautiful cover! You can find it here
May 30, 2024
We are part of the new Collaborative Research Centre 1678 (SFB 1678) "Systemic Consequences of Fidelity Changes in mRNA and Protein Biosynthesis". Here we are investigating factors and pathways that control mRNA homeostasis under cellular stress conditions. Many thanks to Prof. Andreas Beyer from the University of Cologne, who is the spokesperson of the SFB!
May 17, 2024
Our systems-wide study on the dynamics and consequences of RNA isoform changes during human neuronal cell differentiation is published. The study includes a new neuronal cell differentiation model. Big thank you to our collaborators Volker Busskamp, David Meierhofer, Alex Ng and George Church. The article is online now.
August 17, 2023
Our paper on the specific roles of the BET family protein BRD4 in widespread enhancer and target gene transcription is published. The paper also includes a high-sensitive NET-seq approach for more complete RNA-polymerase profiling in mammalian cells. The article is online now.
January 18, 2023
In collaboration with the Reversade Lab (A*STAR, Singapore), we used integrative transcriptomics including spike-in controlled NET-seq to shed light on the mechanisms of a rare progeroid syndrome. The article is online now.
January 13, 2023
Our review article on the roles of BET family proteins in transcription and RNA processing control was selected for the Cover of the January/February Issue of WIREs RNA. Congratulations Nicole and thank you for the beautiful artwork!
September 01, 2022
Our review article on the roles of the BET family protein BRD4 in the regulation of transcription elongation is online. You can find it here.
May 20, 2022
For a general description of our research program check out our latest article in BIOspektrum. Large parts of the article are in German.
May 01, 2022
Our review on the functional roles of BET proteins in transcription and RNA processing regulation is published. You can access it here.
August 13, 2021
An updated version of the NET-seq protocol for mammalian cells is online now. It contains latest enzymes and new kits. You can find it here.
July 28, 2021
Our latest work is online now:
With high-resolution multiomics we provide new insights into the functions of the BET bromodomain protein BRD4 in RNA Pol II transcription regulation.
You can find it here.
May 01, 2021
Jelena Ulicevic receives a prestigious doctoral scholarship from the Studienstiftung des deutschen Volkes. Congratulations Jelena!
April 01, 2021
Our manuscript on widespread DNA sequence induced transcriptional pausing is now published. In this study, we also developed a new NET-seq protocol variant and a peak caller for nucleotide-resolution occupancy data. You can find the manuscript here.
February 15, 2021
Our computational pipeline for the analysis and visualization of functional differences between transcript isoforms is now published. In case of interest you will find it here.
April 08, 2020
Andreas wrote a career advice for young investigators. You can find it here.