Publications

Till Schwaemmle, Gemma Noviello, Eleni Kanata, Jonathan J. Froehlich, Melissa Bothe, Aybuge Altay, Jade Scouarnec, Vivi-Yun Feng, Martin Vingron, Edda G Schulz
Reporter CRISPR screens decipher cis- and trans-regulatory principles at the Xist locus
BioRxiv (2024)
DOI
Edda G. Schulz & Alexandra Martitz
Structural remodeling of the inactive X chromosome during early mouse development
News & Views, Nature Genetics (2024)
DOI
Alexandra Martitz, Edda G. Schulz
Spatial orchestration of the genome: topological reorganisation during X-chromosome inactivation
Review, Current Opinion in Genetics & Development (2024)
DOI
Eleni Kanata, Rachel Duffié, Edda G. Schulz
Establishment and maintenance of random monoallelic expression
Review, Development (2024)
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Mutzel, V.; Schwämmle, T.; Oeverdieck, S.; Librenjak, L.; Boesen, B.; Bothe, M.; Gjaltema, R. A. F.; Dunkel, I.; Noviello, G.; Schulz, E. G.: Antisense transcription can induce expression memory via stable promoter repression. bioRxiv (2024)
MPG.PuRe
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pre-print
Schulz EG.
BREACHing new grounds in fragile X syndrome: Trinucleotide expansion linked to genome-wide heterochromatin domains and genome misfolding
News & Views, Molecular Cell (2024), 84(3), 413-414
DOI
Ravid Lustig L., Sampath Kumar A., Schwämmle T., Dunkel I., Noviello G., Limberg E., Weigert R., Pacini G., Buschow R., Ghauri A., Stötzel M., Wittler L., Meissner A., Schulz EG.
GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers
Nature Cell Biology (2023), 25(11):1704-1715.
DOI
Agostinho de Sousa J, Wong C-W, Dunkel I, Owens T, Voigt P, Hodgson A, Baker D, Schulz EG, Reik W, Smith A, Rostovskaya M, von Meyenn F.
Epigenetic dynamics during capacitation of naïve human pluripotent stem cells.
Science Advances (2023), 9(39): eadg1936.
DOI
Sultana Z, Dorel M, Klinger B, Sieber A, Dunkel I, Blüthgen N, Schulz EG.
Modeling unveils sex differences of signaling networks in mouse embryonic stem cells.
Molecular Systems Biology (2023), e11510.
DOI
Noviello G, Gjaltema RAF, Schulz EG.
CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression.
Nature Communications (2023), 14(1): 3225.
DOI
Iyer, D. P., van der Weijden, V. A., Khoei, H. H., McCarthy, A., Rayon, T., Simon, C. S., Dunkel, I., Wamaitha, S. E., Elder, K., Snell, P., Christie, L., Schulz, E. G., Niakan, K. K., Rivron, N., & Bulut-Karslioglu, A.
Delay of human early development via in vitro diapause.
BioRxiv (2023)
DOI
Noviello G, Gjaltema RAF, Schulz EG.
CasTuner: a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression. 
BioRxiv (2022)
DOI
Ravid Lustig L, Sampath Kumar A, Schwämmle T, Dunkel I, Noviello G, Weigert R, Pacini G, Buschow R, Ghauri A, Stoetzel M, Wittler L, Meissner A, Schulz EG.
GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of a distal enhancer element.
BioRxiv (2022) 
 
DOI
Gjaltema RAF*, Schwämmle T*, Kautz P, Robson M, Schöpflin R, Lustig LR, Brandenburg L, Dunkel I, Vechiatto C, Ntini E, Mutzel V, Schmiedel V, Marsico A, Mundlos S, Schulz EG.
Distal and proximal cis-regulatory elements sense X-chromosomal dosage and developmental state at the Xist locus.
Molecular Cell (2022) 82, 190-208
Source
Genolet O, Ravid Lustig L and Schulz EG.
Dissecting molecular phenotypes through FACS-based pooled CRISPR screens.
Methods Mol Biol. (2022)
 
DOI
Pacini, G, Dunkel, I, Mages, N, Mutzel, V, Timmermann, B, Marsico, A, and Schulz, E G.
Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution
Nature Communications 2021, 12.1, 1–17.
Source
DOI
Genolet, O, Monaco, A A, Dunkel, I, Boettcher, M, and Schulz, E G.
Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach
Genome Biology 2021, 22
Source
DOI
Gjaltema, R A, Schwämmle, T, Kautz, P, Robson, M, Schöpflin, R, Lustig, L R, Brandenburg, L, Dunkel, I, Vechiatto, C, Ntini, E, Mutzel, V, Schmiedel, V, Marsico, A, Mundlos, S, and Schulz, E G.
Distal and proximal cis-regulatory elements sense X-chromosomal dosage and developmental state at the Xist locus
BioRxiv, 2021
Source
Mutzel V &Schulz EG.
Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation.
BioEssays 2020 Apr;42(4):e1900163
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DOI
Barros de Andrade E Sousa L, Jonkers I, Syx L, Dunkel I, Chaumeil J, Picard C, Foret B, Chen CJ, Lis JT, Heard E, Schulz EG, Marsico A.
Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features.
Genome Res. 2019 Jun 7. pii: gr.245027.118. [Epub ahead of print]
Source
DOI
Mutzel V, Okamoto I, Dunkel I, Saitou M, Giorgetti L, Heard E, Schulz EG
A symmetric toggle switch explains the onset of random X inactivation in different mammals.
Nature Structural and Molecular Biology 2019 May;26(5):350-360. Epub 2019 Apr 8.
Source
DOI
Barros de Anrade e Sousa L, Jonkers I, Syx L, Chaumeil J, Picard C, Foret B, Chen C, Lis JT, Heard E, Schulz EG, Marsico A
Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features.
BioRxiv 2019
DOI
Gjaltema RAF, Schulz EG
CRISPR/dCas9 switch systems for temporal transcriptional control
Methods in Molecular Biology, 2018, 1767:167-185
Mutzel V, Okamoto I, Dunkel I, Saitou M, Giorgetti L, Heard E, Schulz EG
Two coupled feedback loops explain random mono-allelic Xist upregulation at the onset of X-chromosome inactivation
BioRxiv, 2017, doi: https://doi.org/10.1101/204909
Source
DOI
Schulz EG
X-chromosome dosage as a modulator of pluripotency, signalling and differentiation?
Philosophical Transactions of the Royal Society B: Biological Sciences, 2017, 372.1733, 20160366
Zhan Y, Mariani L, Barozzi I, Schulz EG, Blüthgen N, Stadler M, Tiana G, Giorgetti L
Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes.
Genome Reseach, 2017 Mar;27(3):479-490
Source
Schulz EG, Meisig J, Nakamura T, Okamoto I, Sieber A, Picard C, Borensztein M, Saitou M, Blüthgen N, Heard E
The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network
Cell Stem Cell, 2014, 14:203-216
Schulz EG, Heard E
Role and control of X chromosome dosage in mammalian development
Current Opinion in Genetics & Development, 2013, 23(2): 109-115
Nora EP, Lajoie BR*, Schulz EG*, Giorgetti L*, Okamoto I, Servant N, Piolot T, van Berkum NL, Meisig J, Sedat J, Gribnau J, Barillot E, Blüthgen N, Dekker J# and Heard E#
Spatial partitioning of the regulatory landscape of the X-inactivation centre
Nature, 2012, 485(7398):381-5
Schulz EG, Nora EP, Heard E
Rnf12 – A Jack of All Trades in X Inactivation
PLoS Genetics, 2011, 7(1): e1002002
Schulz EG, Mariani L, Radbruch A and Höfer T
Sequential polarization and imprinting of type 1 T-helper lymphocytes by interferon-γ and interleukin-12
IMMUNITY, 2009, 30 (5), 673-683
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