Selected publications

Hoehe MR, Church GM, Lehrach H, Kroslak T, Palczewski S, Nowick K, Schulz S, Suk EK, Huebsch T (2014) Multiple haplotype-resolved genomes reveal population patterns of gene and protein diplotypes. Nature Communications 5: 5569. doi: 10.1038/ncomms6569.

Duitama J, McEwen GK, Huebsch T, Palczewski S, Schulz S, Verstrepen K, Suk EK, and Hoehe MR (2012) Fosmid-based whole genome haplotyping of a HapMap trio child: evaluation of Single Individual Haplotyping techniques. Nucleic Acids Res 40: 2041-53.

Suk EK, McEwen GK, Duitama J, Nowick K, Schulz S, Palczewski S, Schreiber S, Holloway DT, McLaughlin S, Peckham H, Lee C, Huebsch T, and Hoehe MR (2011) A Comprehensively Molecular Haplotype-Resolved Genome of a European Individual. Genome Res 21: 1672-1685.

Duitama J, Huebsch T, McEwen G, Suk EK, and Hoehe MR (2010) ReFHap: A reliable and fast algorithm for single individual haplotyping. In: Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology, 160-169. (ACM, Niagara Falls, New York).

Lamina C, Küchenhoff H, Chang-Claude J, Paulweber B, Wichmann H-E, Illig T, Hoehe MR, Kronenberg F, Heid IM (2010) Haplotype misclassification from genotype error and statistical reconstruction and its impact on association estimates. Ann Hum Genet 74: 452-462.

Lunshof JE, Bobe J, Aach J, Angrist M, Thakuria JV, Vorhaus DB, Hoehe MR*, Church GM* (*co-last authors) (2010) Personal genomes in progress: from the Human Genome Project to the Personal Genome Project. Dialogues Clin Neurosci 12: 47-60.

Heid IM, Huth C, Loos RJF, Kronenberg F, Adamkova V, Anand SS, Ardlie K, Biebermann H, Bjerregaard P, Boeing H, Bouchard C, Ciullo M, Cooper JA, Corella D, Dina C, Engert JC, Fisher E, Frances F, Froguel P, Hebebrand J, Hegele RA, Hinney A, Hoehe M, Hu F, Hubacek JA, Humphries SE, Hunt SC, Illig T, Kollerits B, Krude H, Kumar J, Lange LA, Langer B, Li S, Lyon HN, Meyre D, Mohlke KL, Mooser V, Nebel A, Nguyen TT, Paulweber B, Perusse L, Qi L, Rankinen T, Rosskopf D, Schreiber S, Sengupta S, Sorice R, Suk A, Thorleifsson G, Thorsteinsdottir U, Völzke H, Wareham NJ, Waterworth D, Yusuf S, Lange C, Laird N, Hirschhorn JN, and Wichmann H-E (2009) Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design? PLoS Genet Oct;5(10):e1000694.doi:10.1371/journal.pgen.1000694

Hoehe MR (2007): Individual variation in response to mu opiate receptor challenge—past, present, and future: a "personal" history of investigation. Dialogues Clin Neurosci 9:471-475.

Krampe H, Stawicki S, Hoehe MR, Ehrenreich H. Outpatient Long-term Intensive Therapy for Alcoholics (OLITA) (2007): a successful biopsychosocial approach to the treatment of alcoholism. Dialogues Clin Neurosci 9:399-412.

Zhang J, Vingron M, Hoehe MR (2005) Haplotype Reconstruction for Diploid Populations. Hum Hered 59: 144-156. 

Potoczna N, Branson R, Kral JG, Piec G, Steffen R, Ricklin T, Hoehe MR, Lentes K-U, Horber FF (2004) Gene variants and binge eating as predictors of comorbidity and outcome of treatment in severe obesity. J Gastrointest Surg 8: 971-982.

Hoehe MR and Kroslak T (2004) Genetic variation and pharmacogenomics: Concepts, facts, and challenges. Dialogues Clin Neurosci 6: 5-25.

Hoehe MR, Timmermann B, Lehrach H (2003) Human inter-individual DNA sequence variation in candidate genes, drug targets, the importance of haplotypes and implications for pharmacogenomics. Curr Pharm Biotechnol 4: 351-378.

Burgtorf C, Kepper P, Hoehe M, Schmitt C, Reinhardt R, Lehrach H, Sauer S (2003) Clone-based Systematic Haplotyping (CSH) – a procedure for physical haplotyping of whole genomes. Genome Res 13: 2717-2724.

Hoehe MR (2003) Individuelle Genomanalyse als Basis neuer Therapiekonzepte. (Individual genome analysis as the basis for novel therapeutic concepts.) In: Das genetische Wissen und die Zukunft des Menschen. De Gruyter, Berlin, New York, p. 301-317.

Hoehe MR (2003) Haplotypes and the systematic analysis of genetic variation in genes and genomes. Pharmacogenomics 4: 547-570.

Wenzel K, Felix SB, Flachmeier C, Heere P, Schulze W, Grunewald I, Pankow H, Gläser C, Scherneck S, Bauer D and Hoehe MR (2003): Identification and characterization of KAT, a novel gene preferentially expressed in several human cancer cell lines. Biol Chem 384: 763-775.

Franke P, Wendel B, Knapp M, Schwab SG, Neef D, Maier W, Wildenauer DB, Hoehe MR (2003) Introducing a new recruitment approach for genetic association studies in opioid dependence. Eur Psychiat 18: 18-22.

Branson R, Potoczna N, Kral JG, Lentes K-U, Hoehe MR, Horber FF (2003) Binge eating is a major phenotypic characteristic of melanocortin-4 receptor gene mutations. New Engl J Med 348: 1096-1103.

Busjahn A, Freier K, Faulhaber H-D, Li G-H, Rosenthal M, Jordan J, Timmermann B, Hoehe MR, Luft FC (2002) β2 Adrenergic receptor gene variations and coping styles in twins. Biol Psychol 61: 97-109.

Schmidt LG, Samochowiec J., Finckh U, Fiszer-Piosik E., Horodnicki J, Wendel B, Rommelspacher H, Hoehe MR (2002) Association of a CB1 Cannabinoid Receptor Gene (CNR1) Polymorphism with Severe Alcohol Dependence. Drug Alcohol Depend 65: 221-224.

Herrmann SM, Nicaud V, Tiret L, Evans E, Kee F, Ruidavets JB, Arveiler D, Luc G, Morrison C, Hoehe MR, Paul M, Cambien F (2002) Polymorphisms in the ß2-Adrenoceptor (AdrB2) Gene and Essential Hypertension: the ECTIM and PEGASE Studies. J Hypertension 20: 229-235

Patkar AA, Berrettini WH, Hoehe MR, Hill K, Sterling RC, Gottheil E, Weinstein SP (2001) Serotonin transporter (5-HTT) polymorphisms and susceptibility to cocaine-dependence among African-American individuals. Addict Biol 6: 337-345.

Li GH, Faulhaber HD, Rosenthal M, Schuster H, Jordan J, Timmermann B, Hoehe MR, Luft FC, Busjahn A (2001) Beta-2 adrenergic receptor gene variations and blood pressure under stress in normal twins. Psychophysiology 38: 485-489.

Maul B, Siems WE, Hoehe MR, Grecksch G, Bader M, Walther T (2001) Alcohol consumption is controlled by angiotensin II. FASEB J 15: 1640-1642.

Delbrück SJW, Kidd KK, Hoehe, MR (2001) Identification of an additional allelic variant (XLS) of the human serotonin transporter gene (SLC6A4): -1201Cins66. Human Mutation 17: 524.

Kraus J, Börner C, Giannini E, Hickfang K, Braun H, Mayer P., Hoehe MR, Ambrosch A, König W. Höllt V (2001) Regulation of Mu Opioid Receptor Gene Transcription by Interleukin-4 and Influence of an Allelic Variation Within a STAT6 Transcription Factor Binding Site. J Biol Chem 276: 43901-43908.

Befort K, Filliol D, Decaillot FM, Gaveriaux-Ruff C, Hoehe MR, Kieffer BL (2001) A Single Nucleotide Polymorphic Mutation in the Human µ-Opioid Receptor Severely Impairs Receptor Signaling. J Biol Chem 276: 3130-3137.

Hoehe MR, Köpke K, Wendel B, Flachmeier C, Kidd KK, Berrettini WH, Church GM (2000) Sequence variability and candidate gene analysis in complex disease: Association of μ Opioid Receptor Gene Variation with Substance Dependence. Hum Mol Genet 19: 2895-2908.

Wenzel, K., Felix, S.B., Heere, P., Flachmeier, C., Podlowski, S., Koepke, K., Hoehe, M.R. (2000) Novel variants in the 5’UTR of the beta1-adrenergic receptor gene (– 93T>C, –210C>T, – 2146T>C): - 2146C homozygotes present in patients with idiopathic dilated cardiomyopathy and coronary heart disease. Human Mutation 16: 534.

Podlowski S, Wenzel K, Luther HP, Müller J, Bramlage P, Baumann G, Felix SB, Speer A, Hetzer R, Köpke K, Hoehe MR, Wallukat G (2000) Human b1-Adrenoceptor Gene Variation: A Role in Idiopathic Dilated Cardiomyopathy? J Mol Med 78: 87-93.

Hoehe MR, Rinn T, Flachmeier C, Heere P, Kunert HJ, Timmermann B, Köpke K, Ehrenreich H (2000) Comparative sequencing of the human CB1 cannabinoid receptor gene (CNR1) coding exon: no structural mutations in individuals exhibiting extreme responses to cannabis. Psychiat Genet 10:173-177.

Busjahn A, Li G-H, Faulhaber H-D, Rosenthal M, Jeschke E, Schuster H, Timmermann B, Hoehe MR, Luft FC (2000) β₂ Adrenergic Receptor Gene Variations, Blood Pressure, and Heart Size In Normal Twins. Hypertension 35: 555-560.

Wendel B, Reinhardt R, Wachtendorf U, Zacharzowsky UB, Osterziel KJ, Schulte HD, Haase H, Hoehe MR, Morano I (2000) The human ß-myosin heary chain gene: sequence diversity and functional characteristics of the protein. J Cell Biochem 79: 566-575.

Busjahn A, Knoblauch H, Faulhaber H-D, Böckel T, Rosenthal M, Uhlmann R, Hoehe MR, Schuster H, and Luft FC (1999) The QT interval is linked to two long-QT syndrome loci in normal subjects. Circulation 99: 3161-3164.

Gratze G, Fortin J, Labugger R, Binder A, Kotanko P, Timmermann B, Luft FC, Hoehe MR, and Skrabal F (1999) beta-2 Adrenergic Receptor Variants Affect Resting Blood Pressure and Agonist-induced Vasodilation in Normotensive Caucasians. Hypertension 33: 1425-1430.

Wendel BC and Hoehe MR (1998) The human μ opioid receptor gene: 5’ regulatory and intronic sequences. J Mol Med 76: 525-532.