Professor Dr. H.-Hilger Ropers

Professor Dr. H.-Hilger Ropers

Emeritus Scientific Member

H.Hilger Ropers studied medicine at the Universities of Freiburg and Munich. He received his M.D. in 1972 and his habilitation in the field of Human Genetics in 1978 from the University of Freiburg where he worked at the Institute of Human Genetics. From 1984 until 1997 he was Professor and Head of the Department of Human Genetics at the University of Nijmegen (NL) and since 1994 Director at the Max Planck Institute for Molecular Genetics in Berlin.

In the past, Ropers and his group have successfully employed positional cloning and related strategies to elucidate molecular defects underlying various genetic disorders, including inherited forms of blindness, deafness and mental retardation. His current focus is the systematic elucidation of early onset cognitive defects and related disorders, particularly X-chromosomal and autosomal recessive forms. “Next Generation Sequencing” and “Genome Partitioning” methods are being employed which are about to revolutionize genetic research and health care.

H.Hilger Ropers is member of numerous international organizations. He is appointed member of the Royal Netherlands Academy of Arts and Sciences and of the Berlin-Brandenburg Academy of Sciences (BBAW). Since 2008 he heads the Biomedical Class of the BBAW.

Selected publications

1.
Najmabadi H, Hu H, Garshasbi M, Zemojtel T, Abedini SS, Chen W, Hosseini M, Behjati F, Haas S, Jamali P, Zecha A, Mohseni M, Püttmann L, Vahid LN, Jensen C, Moheb LA, Bienek M, Larti F, Mueller I, Weissmann R, Darvish H, Wrogemann K, Hadavi V, Lipkowitz B, Esmaeeli-Nieh S, Wieczorek D, Kariminejad R, Firouzabadi SG, Cohen M, Fattahi Z, Rost I, Mojahedi F, Hertzberg C, Dehghan A, Rajab A, Banavandi MJ, Hoffer J, Falah M, Musante L, Kalscheuer V, Ullmann R, Kuss AW, Tzschach A, Kahrizi K, Ropers HH
Deep sequencing reveals 50 novel genes for recessive cognitive disorders.
Nature 2011 Sep 21;478(7367):57-63.
2.
H.-Hilger Ropers
Genetics of early onset cognitive impairment.
Annual Review of Genomics and Human Genetics 2010;11:161-87.
3.
H.-Hilger Ropers
Single gene disorders come into focus--again.
Dialogues in clinical neuroscience 2010;12(1):95-102.
4.
Chen W, Kalscheuer V, Tzschach A, Menzel C, Ullmann R, Schulz MH, Erdogan F, Li N, Kijas Z, Arkesteijn G, Pajares IL, Goetz-Sothmann M, Heinrich U, Rost I, Dufke A, Grasshoff U, Glaeser B, Vingron M, Ropers HH.
Mapping translocation breakpoints by next-generation sequencing.
Genome Research 2008 Jul;18(7):1143-9
5.
H.-Hilger Ropers
Genetics of intellectual disability.
Current Opinion in Genetics & Development 2008 Jun;18(3):241-50.  Epub 2008 Aug 28.

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