Déborah Bourc'his: Protect or program: the dichotomy of DNA methylation in spermatogenesis

DNA methylation is a prevalent epigenetic mark in mammalian genomes, with essential roles for development. Over the past years, our team has made significant contribution in understanding the role of this mark for spermatogenesis and male fertility. I will present our latest work that demonstrates that sperm production relies on a division of labor between two DNA methylation enzymes, with specialized and non-redundant functions in developing germ cells: transposon control or stem cell homeostasis.