Nanocourse: Growth Factor Signalling Interplay with Cell Mechanics
- Beginn: 30.03.2020
- Ende: 01.04.2020
- Vortragende: Christian Hiepen, Paul Menzel, Sigmar Stricker, Petra Knaus
- Ort: FU Berlin, Institute for Chemistry and Biochemistry, Thielallee 63
- Raum: 2nd floor Seminar Room, Knaus Lab
- Gastgeber: Petra Knaus
Please register for this course by emailing firstname.lastname@example.org
Theoretical aspects of the workshop will cover
- basic concepts in cell-sensation of mechanical cues
- integration of extracellular matrix (ECM) biology and external mechanical cues into intracellular signalling pathways (Petra Knaus, Chris Hiepen, Paul Menzel)
- coupling of mechanobiology with chromatin architecture and gene transcription (Sigmar Stricker, Petra Knaus).
Practical aspects will highlight technologies
- to apply and measure cellular forces
- to investigate on the cell’s force sensing machinery, in particular its subcellular localization (Chris Hiepen, Maria Reichenbach)
- in-silico prediction of genes that underly mechano-dependent regulation (Jerome Jatzlau)
We will focus in theory and practice on the vasculature, where blood-vessel forming cells (endothelial cells) continuously sense mechanical stimuli and integrate them into their cellular behavior.
The students will review and present primary research articles and discuss state of art data and concepts in mechanobiology and growth factor signal transduction.
This workshop is particularly suited for students who want to work at the translational interface of physics, bioinformatics and cell biology. Students should bring their laptops.