Despite their constant genome sequence, cells of multicellular organisms have different morphologies and functions due to the execution distinct gene ex- pression programs. In this context, transcriptional regulation is very important, as it controls the production rate of mRNAs, which together with the degradation rate determines the steady state level of mRNAs. Transcriptional control depends on the action of transcription factors, which bind to distinct DNA sequences in so-called cis-regulatory elements. These binding events in turn influence the recruitment and activity of RNA polymerases.
- 2000: Diploma in Biology from Julius-Maximilians-Universität Würzburg (Germany) / Rockefeller University, New York (USA)
- 2004: PhD from Technische Universität Carolo-Wilhelmina Braunschweig / Max Planck Institute for Biophysical Chemistry Göttingen (Germany)
- 2005-2011: PostDoc in the department of Computational Molecular Biology at the Max Planck Institute for Molecular Genetics, Berlin (Germany)
- since 09/2011: Max Planck Research Group Leader at the Max Planck Institute for Molecular Genetics in Berlin (Germany)