Are there two classes of promoters?
Research report (imported) 2013 - Max Planck Institute for Molecular Genetics
A mathematical analysis of human gene promoter sequences shows that these promoters fall into two distinct classes. A number of features correlate with these two classes, suggesting that this distinction is actually a reflection of different regulatory mechanisms. This article summarizes sequence features and biological properties specific for the promoters of the two classes. We explain how a mathematical analysis of whole-genome data could point towards particular biological mechanisms.