Dr. Denes Hnisz
The mission of the Hnisz laboratory is to discover principles that underlie control of transcriptional programs during development and disease. We recently proposed a model that transcriptional regulatory proteins can form phase- separated ‘transcriptional condensates’ that may play important roles in the control of cell identity of mammalian cells. The central theme of the lab is to use the transcriptional condensate model to solve major outstanding problems in transcription- developmental- and disease biology. Successful candidates will develop projects investigating the molecular basis of transcriptional condensate formation, investigating the regulatory functions of transcriptional condensates, and elucidating their roles in various developmental and disease contexts.