Tissue-specific differential methylation as a driving force for CpG Island evolution

Dr. Peter Arndt

September 30, 2021

Keywords: DNA methylation, CpG-Island evolution, NGS data analysis, Bayesian Statistics

DNA methylation is a major epigenetic modification important for regulating gene expression. Methylation occurs at CpG sites, which through evolution are often concentrated in CpG Islands associated to gene promoters. We want to understand this evolutionary process, which is responsible for the emergence and maintenance of CpG Islands. The assumption is that the ability to differentially regulate genes in different tissues is one of the driving forces. With newest sequencing technologies we can scan the genome in different tissues for differentially methylated sites allowing us to quantify this effect. 

Requirements are a Master or Diploma in Physics, Mathematics, Biology or another relevant field. The ideal candidate would have a strong interest in evolution and experience in the analysis of Next Generation Sequencing data.

Possible collaboration partners for this project within the IMPRS-BAC are the groups of Prof. Dr. Alexander Meissner and Dr. Ralf Herwig.

For more information visit the website of the Evolutionary Genomics Group.

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