Publications (2009-2016)
Weidner C, Rousseau M, Plauth A, Wowro SJ, Fischer C, Abdel-Aziz H, Sauer S. Iberis amara Extract Induces Intracellular Formation of Reactive Oxygen Species and Inhibits Colon Cancer. PLoS One. 2016 Apr 6;11(4):e0152398.
Conrad T, Albrecht AS, de Melo Costa VR, Sauer S, Meierhofer D, Ørom UA. Serial interactome capture of the human cell nucleus. Nat Commun. 2016 Apr 4;7:11212.
Telorac J, Prykhozhij SV, Schöne S, Meierhofer D, Sauer S, Thomas-Chollier M, Meijsing SH. Identification and characterization of DNA sequences that prevent glucocorticoid receptor binding to nearby response elements. Nucleic Acids Res. 2016 Mar 25. pii: gkw203. [Epub ahead of print]
Volckmar AL, Han CT, Pütter C, Haas S, Vogel CI, Knoll N, Struve C, Göbel M, Haas K, Herrfurth N, Jarick I, Grallert H, Schürmann A, Al-Hasani H, Hebebrand J, Sauer S, Hinney A. Analysis of Genes Involved in Body Weight Regulation by Targeted Re-Sequencing. PLoS One. 2016 Feb 1;11(2):e0147904.
Luge T, Sauer S. Generating Sample-Specific Databases for Mass Spectrometry-Based Proteomic Analysis by Using RNA Sequencing. Methods Mol Biol. 2016;1394:219-32.
Weidner C, Rousseau M, Micikas RJ, Fischer C, Plauth A, Wowro SJ, Siems K, Hetterling G, Kliem M, Schroeder FC, Sauer S. Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria. J Nat Prod. 2016 Jan 22;79(1):2-12.
Kremer LS, Distelmaier F, Alhaddad B, Hempel M, Iuso A, Küpper C, Mühlhausen C, Kovacs-Nagy R, Satanovskij R, Graf E, Berutti R, Eckstein G, Durbin R, Sauer S, Hoffmann GF, Strom TM, Santer R, Meitinger T, Klopstock T, Prokisch H, Haack TB. Biallelic Truncating Mutations in TANGO2 Cause Infancy-Onset Recurrent Metabolic Crises with Encephalocardiomyopathy. Am J Hum Genet. 2016 Jan 19. pii: S0002-9297(15)00504-2. doi: 10.1016/j.ajhg.2015.12.009. [Epub ahead of print]
Madrigal I, Alvarez-Mora MI, Rosell J, Rodríguez-Revenga L, Karlberg O, Sauer S, Syvänen AC, Mila M. A novel splicing mutation in the IQSEC2 gene that modulates the phenotype severity in a family with intellectual disability. Eur J Hum Genet. 2016 Jan 6. doi: 10.1038/ejhg.2015.267. [Epub ahead of print]
Lopes F, Barbosa M, Ameur A, Soares G, de Sá J, Dias AI, Oliveira G, Cabral P, Temudo T, Calado E, Cruz IF, Vieira JP, Oliveira R, Esteves S, Sauer S, Jonasson I, Syvänen AC, Gyllensten U, Pinto D, Maciel P. Identification of novel genetic causes of Rett syndrome-like phenotypes. J Med Genet. 2016 Jan 6. pii: jmedgenet-2015-103568. doi: 10.1136/jmedgenet-2015-103568. [Epub ahead of print]
Cui H, Schlesinger J, Schoenhals S, Tönjes M, Dunkel I, Meierhofer D, Cano E, Schulz K, Berger MF, Haack T, Abdelilah-Seyfried S, Bulyk ML, Sauer S, Sperling SR. Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA. Nucleic Acids Res. 2015 Nov 17. pii: gkv1244. [Epub ahead of print]
McGinn S, Bauer D, Brefort T, Dong L, El-Sagheer A, Elsharawy A, Evans G, Falk-Sörqvist E, Forster M, Fredriksson S, Freeman P, Freitag C, Fritzsche J, Gibson S, Gullberg M, Gut M, Heath S, Heath-Brun I, Heron AJ, Hohlbein J, Ke R, Lancaster O, Le Reste L, Maglia G, Marie R, Mauger F, Mertes F, Mignardi M, Moens L, Oostmeijer J, Out R, Pedersen JN, Persson F, Picaud V, Rotem D, Schracke N, Sengenes J, Stähler PF, Stade B, Stoddart D, Teng X, Veal CD, Zahra N, Bayley H, Beier M, Brown T, Dekker C, Ekström B, Flyvbjerg H, Franke A, Guenther S, Kapanidis AN, Kaye J, Kristensen A, Lehrach H, Mangion J, Sauer S, Schyns E, Tost J, van Helvoort JM, van der Zaag PJ, Tegenfeldt JO, Brookes AJ, Mir K, Nilsson M, Willcocks S, Gut IG. New technologies for DNA analysis - a review of the READNA Project. N Biotechnol. 2015 Oct 26. pii: S1871-6784(15)00163-6. doi: 10.1016/j.nbt.2015.10.003. [Epub ahead of print] Review.
Limbach M, Saare M, Tserel L, Kisand K, Eglit T, Sauer S, Axelsson T, Syvänen AC, Metspalu A, Milani L, Peterson P. Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling. J Autoimmun. 2015 Oct 9. pii: S0896-8411(15)30045-7. doi: 10.1016/j.jaut.2015.09.006. [Epub ahead of print]
Sauer S. Ligands for the Nuclear Peroxisome Proliferator-Activated Receptor Gamma. Trends Pharmacol Sci. 2015 Oct;36(10):688-704
Frommer A, Hjeij R, Loges NT, Edelbusch C, Jahnke C, Raidt J, Werner C, Wallmeier J, Große-Onnebrink J, Olbrich H, Cindrić S, Jaspers M, Boon M, Memari Y, Durbin R, Kolb-Kokocinski A, Sauer S, Marthin JK, Nielsen KG, Amirav I, Elias N, Kerem E, Shoseyov D, Haeffner K, Omran H. Immunofluorescence Analysis and Diagnosis of Primary Ciliary Dyskinesia with Radial Spoke Defects. Am J Respir Cell Mol Biol. 2015 Oct;53(4):563-73.
Egerer J, Emmerich D, Fischer-Zirnsak B, Chan WL, Meierhofer D, Tuysuz B, Marschner K, Sauer S, Barr FA, Mundlos S, Kornak U. GORAB Missense Mutations Disrupt RAB6 and ARF5 Binding and Golgi Targeting. J Invest Dermatol. 2015 Oct;135(10):2368-76
Kaiser VB, Svinti V, Prendergast JG, Chau YY, Campbell A, Patarcic I, Barroso I, Joshi PK, Hastie ND, Miljkovic A, Taylor MS; Generation Scotland; UK10K, Enroth S, Memari Y, Kolb-Kokocinski A, Wright AF, Gyllensten U, Durbin R, Rudan I, Campbell H, Polašek O, Johansson Å, Sauer S, Porteous DJ, Fraser RM, Drake C, Vitart V, Hayward C, Semple CA, Wilson JF. Homozygous loss-of-function variants in European cosmopolitan and isolate populations. Hum Mol Genet. 2015 Oct 1;24(19):5464-74
Correia JC, Massart J, de Boer JF, Porsmyr-Palmertz M, Martínez-Redondo V, Agudelo LZ, Sinha I, Meierhofer D, Ribeiro V, Björnholm M, Sauer S, Dahlman-Wright K, Zierath JR, Groen AK, Ruas JL. Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism. Mol Metab. 2015 Sep 26;4(12):891-902.
Wittig M, Anmarkrud JA, Kässens JC, Koch S, Forster M, Ellinghaus E, Hov JR, Sauer S, Schimmler M, Ziemann M, Görg S, Jacob F, Karlsen TH, Franke A. Development of a high-resolution NGS-based HLA-typing and analysis pipeline. Nucleic Acids Res. 2015 Jun 23;43(11):e70
Haack TB, Jackson CB, Murayama K, Kremer LS, Schaller A, Kotzaeridou U, de Vries MC, Schottmann G, Santra S, Büchner B, Wieland T, Graf E, Freisinger P, Eggimann S, Ohtake A, Okazaki Y, Kohda M, Kishita Y, Tokuzawa Y, Sauer S, Memari Y, Kolb-Kokocinski A, Durbin R, Hasselmann O, Cremer K, Albrecht B, Wieczorek D, Engels H, Hahn D, Zink AM, Alston CL, Taylor RW, Rodenburg RJ, Trollmann R, Sperl W, Strom TM, Hoffmann GF, Mayr JA, Meitinger T, Bolognini R, Schuelke M, Nuoffer JM, Kölker S, Prokisch H, Klopstock T. Deficiency of ECHS1 causes mitochondrial encephalopathy with cardiac involvement. Ann Clin Transl Neurol. 2015 May;2(5):492-509.
Fuhr L, Rousseau M, Plauth A, Schroeder FC, Sauer S. Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties. J Nat Prod. 2015 May 22;78(5):1160-4.
Llewellyn MS, Messenger LA, Luquetti AO, Garcia L, Torrico F, Tavares SB, Cheaib B, Derome N, Delepine M, Baulard C, Deleuze JF, Sauer S, Miles MA. Deep Sequencing of the Trypanosoma cruzi GP63 Surface Proteases Reveals Diversity and Diversifying Selection among Chronic and Congenital Chagas Disease Patients. PLoS Negl Trop Dis. 2015 Apr 7;9(4):e0003458.
Sauer S, Luge T. Nutriproteomics: Facts, concepts, and perspectives. Proteomics. 2015 Mar;15(5-6):997-1013.
Simandi Z, Czipa E, Horvath A, Koszeghy A, Bordas C, Póliska S, Juhász I, Imre L, Szabó G, Dezso B, Barta E, Sauer S, Karolyi K, Kovacs I, Hutóczki G, Bognár L, Klekner Á, Szucs P, Bálint BL, Nagy L. PRMT1 and PRMT8 Regulate Retinoic Acid-Dependent Neuronal Differentiation with Implications to Neuropathology. Stem Cells. 2015 Mar;33(3):726-41.
Meierhofer D, Weidner C, Sauer S. Correction to "integrative analysis of transcriptomics, proteomics, and metabolomics data of white adipose and liver tissue of high-fat diet and rosiglitazone-treated insulin-resistant mice identified pathway alterations and molecular hubs". J Proteome Res. 2015 Mar 6;14(3):1643-4.
Weidner C, Rousseau M, Plauth A, Wowro SJ, Fischer C, Abdel-Aziz H, Sauer S. Melissa officinalis extract induces apoptosis and inhibits proliferation in colon cancer cells through formation of reactive oxygen species. Phytomedicine. 2015 Feb 15;22(2):262-270.
Aidhen IS, Mukkamala R, Weidner C, Sauer S. A common building block for the syntheses of amorfrutin and cajaninstilbene acid libraries toward efficient binding with peroxisome proliferator-activated receptors. Org Lett. 2015 Jan 16;17(2):194-7.
2014
Meierhofer D, Weidner C, Sauer S. Integrative analysis of transcriptomics, proteomics, and metabolomics data
of white adipose and liver tissue of high-fat diet and rosiglitazone-treated insulin-resistant mice identified pathway alterations and molecular hubs. J Proteome Res. 2014 Dec 5;13(12):5592-602. doi: 10.1021/pr5005828.
Madrigal I, Alvarez-Mora MI, Karlberg O, Rodríguez-Revenga L, Elurbe DM, Rabionet R, Mur A, Pie J, Ballesta F, Sauer S, Syvänen AC, Milà M. Efficient application of next-generation sequencing for the diagnosis of rare genetic syndromes. J Clin Pathol. 2014 Dec;67(12):1099-103. doi: 10.1136/jclinpath-2014-202537.
Weidner C, Fischer C, Sauer S. PHOXTRACK - a tool for interpreting comprehensive datasets of post-translational modifications of proteins. Bioinformatics. 2014 Dec 1;30(23):3410-1. doi: 10.1093/bioinformatics/btu572.
Almouzni G, Altucci L, Amati B, Ashley N, Baulcombe D, Beaujean N, Bock C, Bongcam-Rudloff E, Bousquet J, Braun S, de Paillerets BB, Bussemakers M, Clarke L, Conesa A, Estivill X, Fazeli A, Grgurevi NA, Gut I, Heijmans BT, Hermouet S, Houwing Duistermaat J, Iacobucci I, Ila J, Kandimalla R, Krauss-Etschmann S, Lasko P, Lehmann S, Lindroth A, Majdi G, Marcotte E, Martinelli G, Martinet N, Meyer E, Miceli C, Mills K, Moreno-Villanueva M, Morvan G, Nickel D, Niesler B, Nowacki M, Nowak J, Ossowski S, Pelizzola M, Pochet R, Poto Nik U, Radwanska M, Raes J, Rattray M, Robinson MD, Roelen B, Sauer S, Schinzer D, Slagboom E, Spector T, Stunnenberg HG, Tiligada E, Torres-Padilla ME, Tsonaka R, Van Soom A, Vidakovi M, Widschwendter M. Relationship between genome and epigenome - challenges and requirements for future research. BMC Genomics. 2014 Jun 18;15(1):487.
Luge T, Kube M, Freiwald A, Meierhofer D, Seemüller E, Sauer S. Transcriptomics assisted proteomic analysis of Nicotiana occidentalis infected by Candidatus Phytoplasma mali strain AT. Proteomics. 2014 Aug;14(16):1882-9. doi: 10.1002/pmic.201300551.
Sauer S. Amorfrutins: A Promising Class of Natural Products that Are Beneficial to Health. Chembiochem. 2014 Jun 16;15(9):1231-8.
Siewert C, Luge T, Duduk B, Seemüller E, Büttner C, Sauer S, Kube M. Analysis of expressed genes of the bacterium 'Candidatus phytoplasma Mali' highlights key features of virulence and metabolism. PLoS One. 2014 Apr 11;9(4):e94391.
2013
Sauer S. Diagnostic proteomics: will this impact the clinic? Proteomics Clin Appl. 2013 Dec;7(11-12):725-6.
Freiwald A, Weidner C, Witzke A, Huang SY, Meierhofer D, Sauer S. Comprehensive proteomic data sets for studying adipocyte-macrophage cell-cell communication. Proteomics. 2013 Oct 31. doi: 10.1002/pmic.201300271. [Epub ahead of print]
Weidner C, Wowro SJ, Freiwald A, Kodelja V, Abdel-Aziz H, Kelber O, Sauer S. Lemon balm extract causes potent antihyperglycemic and antihyperlipidemic effects in insulin-resistant obese mice. Mol Nutr Food Res. 2013 Nov 24. doi: 10.1002/mnfr.201300477.
Weidner C, Wowro SJ, Rousseau M, Freiwald A, Kodelja V, Abdel-Aziz H, Kelber O, Sauer S. Antidiabetic Effects of Chamomile Flowers Extract in Obese Mice through Transcriptional Stimulation of Nutrient Sensors of the Peroxisome Proliferator-Activated Receptor (PPAR) Family. PLoS One. 2013 Nov 12;8(11):e80335. doi: 10.1371/journal.pone.0080335.
Sauer S. Protein set analyses: how could this impact the clinic? Expert Rev Proteomics. 2013 Aug;10(4):305-7. doi: 10.1586/14789450.2013.814883. No abstract available. Erratum in: Expert Rev Proteomics. 2013 Oct;10(5):503. link
Weidner C, Wowro SJ, Freiwald A, Kawamoto K, Witzke A, Kliem M, Siems K, Müller-Kuhrt L, Schroeder FC, Sauer S. Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARγ) agonist with potent glucose-lowering properties. Diabetologia, vol. 56, no. 8, pp. 1802–1812, Aug. 2013.
Sauer S. Mikrobielle Diagnostik mittels Massenspektrometrie. Biospektrum 2013, May, 3, 256-257.
Meierhofer D, Weidner C, Hartmann L, Mayr JA, Han CT, Schroeder FC, Sauer S (2013) Protein sets define disease states and predict in vivo effects of drug treatment. Mol. Cell Proteomics, vol. 12, no. 7, pp. 1965–1979, Jul. 2013.
Holzhauser S, Freiwald A, Weise C, Multhaup G, Han CT, Sauer S (2013) Discovery and Characterization of Protein-Modifying Natural Products by MALDI Mass Spectrometry Reveal Potent SIRT1 and p300 Inhibitors. Angew Chem Int Ed Engl. 2013 May 3;52(19):5171-4.
de Groot JC, Weidner C, Krausze J, Kawamoto K, Schroeder FC, Sauer S, Bussow K (2013) Structural Characterization of Amorfrutins Bound to the Peroxisome Proliferator-Activated Receptor gamma. J. Med. Chem., vol. 56, no. 4, pp. 1535–1543, Feb. 2013.
Feldmann R, Fischer C, Kodelja V, Behrens S, Haas S, Vingron M, Timmermann B, Geikowski A, Sauer S (2013) Genome-wide analysis of LXRalpha activation reveals new transcriptional networks in human atherosclerotic foam cells. Nucleic Acids Res 41:3518-3531
Feldmann R, Geikowski A, Weidner C, Witzke A, Kodelja V, Schwarz T, Gabriel M, Erker T, Sauer S (2013) Foam cell specific LXRalpha ligand. PLoS One 8:e57311
Weimann M, Grossmann A, Woodsmith J, Ozkan Z, Birth P, Meierhofer D, Benlasfer N, Valovka T, Timmermann B, Wanker EE, Sauer S, Stelzl U (2013) A Y2H-seq approach defines the human protein methyltransferase interactome. Nat Methods. 2013 Apr;10(4):339-42.
2012
Kliem M, Sauer S (2012). The essence on mass spectrometry based microbial diagnostics. Curr Opin Microbiol 15:1–6
Weidner C, de Groot JC, Prasad A, Freiwald A, Quedenau C, Kliem M, Witzke A, Kodelja V, Han CT, Giegold S, Baumann M, Klebl B, Siems K, Müller-Kuhrt L, Schürmann A, Schüler R, Pfeiffer AF, Schroeder FC, Büssow K, Sauer S (2012). Amorfrutins are potent antidiabetic dietary natural products. Proc Natl Acad Sci U S A 109(19):7257-62
2011
Freiwald A, Mao L, Kodelja V, Kliem M, Schuldt D, Schreiber S, Franke A, Sauer S (2011). Differential analysis of Crohn’s disease and ulcerative colitis by mass spectrometry. Inflamm Bowel Dis 17(4):1051-2
Mertes F, Elsharawy A, Sauer S, van Helvoort JM, van der Zaag PJ, Franke A, Nilsson M, Lehrach H, Brookes AJ (2011). Targeted enrichment of genomic DNA regions for next-generation sequencing. Brief Funct Genomics 10(6):374-86
2010
Haseneyer G, Stracke S, Piepho HP, Sauer S, Geiger HH, Graner A (2010). DNA polymorphisms and haplotype patterns of transcription factors involved in barley endosperm development are associated with key agronomic traits. BMC Plant Biol 10:5
Konrad K, Dempfle A, Friedel S, Heiser P, Holtkamp K, Walitza S, Sauer S, Warnke A, Remschmidt H, Gilsbach S, Schäfer H, Hinney A, Hebebrand J, Herpertz-Dahlmann B (2010). Familiality and molecular genetics of attention networks in ADHD. Am J Med Genet B Neuropsychiatr Genet 153B(1):148-58
Sauer S, Kliem M (2010). Mass spectrometry tools for the classification and identification of bacteria. Nature Rev Microbiol 8(1):74-82
2009
Baek YS, Haas S, Hackstein H, Bein G, Hernandez-Santana M, Lehrach H, Sauer S, Seitz H. Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells. BMC Immunol 10:18
Darii E, Lebeau D, Papin N, Rubina AY, Stomakhin A, Tost J, Sauer S, Savvateeva E, Dementieva E, Zasedatelev A, Makarov AA, Gut IG (2009). Quantification of target proteins using hydrogel antibody arrays and MALDI time-of-flight mass spectrometry (A2M2S). N Biotechnol 25(6):404-16
Freiwald A, Sauer S (2009). Phylogenetic classification and identification of bacteria by mass spectrometry. Nat Protoc 4(5):732-42
Stracke S, Haseneyer G, Veyrieras JB, Geiger HH, Sauer S, Graner A, Piepho HP. Association mapping reveals gene action and interactions in the determination of flowering time in barley. Theor Appl Genet 118(2):259-73