Meijsing lab / Mechanisms of Transcriptional Regulation Group

Research concept

Using the glucocorticoid receptor (GR) as a model transcription factor whose activity is strictly controlled by the presence of hormone, my group uses integrative experimental, structural and computational modeling approaches, with the ultimate goal to qualitatively and quantitatively explain the genome-wide transcriptional consequences of GR signaling. Specific aims include: (i) Understanding how the integration of signals, especially the sequence of DNA binding site, fine-tune the activity of GR towards individual target genes; (ii) Linking genomic GR binding to the regulation of endogenous target genes; (iii) Identifying mechanisms that specify where and when GR target genes are expressed and eventually how they contribute to GR’s physiological and therapeutical roles.

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