Publications
Kacprzyk L.A.; Laible M; Andrasiuk T.; Brase J.C.; Börno S.T.; Fälth M.; Kuner R.; Lehrach H., Schweiger M.R.; and H. Sültmann. ERG Induces Epigenetic Activation of Tudor Domain-containing Protein 1 (TDRD1) in ERG Rearrangement-positive Prostate Cancer. PlosOne accepted
Schweiger M.R., Hussong M., Röhr C and H.Lehrach. Genomics and Epigenomics of Colorectal Cancer. Wiley Interdiscip Rev Syst Biol Med. 2013 Jan 16
Bu H., Schweiger M.R., Manke T., Wunderlich A., Timmermann B., Kerick M., Fuchsberger C., Cato A.C.B. and H.Klocker. Anterior gradient 2 and 3: two prototype androgen responsive genes transcriptionally upregulated by androgens and by estrogens in prostate cancer cells. FEBS J, 2013 Jan 7
Grimm C., Chavez L., Vilardell M., Farrall A.L., Tierling S., Böhm J.W., Grote P., Lienhard M., Timmermann B., Walter J., Schweiger M.R., Lehrach H., Herwig R., Herrmann B.G. and M. Morkel. DNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancer. PLOS Genetics, accepted
Schweiger M.R., Hussong M., Röhr C. and H.Lehrach. Genomics and Epigenomics of Colorectal Cancer. Wiley Interdiscip Rev Syst Biol Med. accepted
Börno S.T., Fischer A., Kerick M., Fälth M., Laible M., Brase J.C., Kuner R., Dahl A., Grimm C., Sayanjali B., Isau M., Roehr C., Wunderlich A., Timmermann B., Claus R., Plass C., Graefen M., Simon R., Demichelis F., Rubin M., Sauter G., Schlomm T., Sültmann H., Lehrach H. and M.R. Schweiger. Genome-wide DNA methylation events in TMPRSS2:ERG fusion negative prostate cancers implicate an EZH2 dependent mechanism with miRNA-26a hypermethylation. Cancer Discov. 2012 Nov;2(11):1024-35
Querfurth R, Fischer A, Schweiger MR, Lehrach H, Mertes F. Creation and application of immortalized bait libraries for targeted enrichment and next-generation sequencing. Biotechniques. 2012 Jun;52(6):375-80.
Haupt A, Joberty G, Bantscheff M, Frohlich H, Stehr H, Schweiger MR, Fischer A, Kerick M, Boerno ST, Dahl A, Lappe M, Lehrach H, Gonzalez C, Drewes G, Lange BM. Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics. BMC Cancer. 2012 Jan 25;12(1):38
Meinel T., Schweiger M.R., Ludewig A.H., Ramu C., Preissner R., Lehrach H., Krobitsch S. and R. Herwig. Ortho2ExpressMatrix: interpreting cross-species high-throughput experiments with gene family information. BMC Genomics, 2011 Oct 4;12:483.
Kerick MѲ, Isau MѲ, Timmermann B, Sueltmann H, Krobitsch S, Bartsch G, Schaefer G, Klocker H, Lehrach H, Schweiger MR (2011). Technical challenges of targeted DNA Enrichment to Identify Genetic Variations in Cancer Patients. BMC Medical Genomics 4:68 Ѳ shared co- first authors
Kohlmann A, Klein H.U., Weissmann S., Bresolin S., Chaplin T., Cuppens H., Garicochea B.,Grossmann V., Hanczaruk B., Hebestreit K., Hofer K., Iacobucci I., Jansen J.H., Kronnie T., Locht L., Martinelli G., McGowan K., Stabentheiner S.,Schweiger M.R., Timmermann B., Vandenberghe P., Young B.D.,Dugas M. and Torsten Haferlach1
The Interlaboratory Robustness of Next-Generation Sequencing (IRON) Study: Deep-Sequencing Investigating TET2, CBL, and KRAS Mutations in 5,580 Amplicons by an International Consortium Involving 10 Laboratories. Leukemia. 2011 Dec;25(12):1840-8
Krueger A., Gruening N.M., Wameling M.M.C., Kerick M., Kirpy A., Parkhomchuk D., Schweiger M.R., Soldatov A., Lehrach H., Jakobs C. and Ralser M. The pentose phosphate pathway is a metabolic redox sensor. Antioxid Redox Signal. 2011 Feb 25
Roedelsperger C., Krawitz P., Bauer S., Hecht J., Bigham A.W., Bamshad M., de Condor B.J., Schweiger M.R. and P. Robinson. Identity-By-Descent Filtering of Exome Sequence data for Disease-Gene Identification in Autosomal Recessive Disorders. Bioinformatics. 2011 Jan 28
Schweiger M.R., Kerick M., Timmermann B. and M.Isau. The power of NGS technologies to delineate the genome organization in cancer: From mutations to structural variations and epigenetic alterations. Cancer Metastasis Rev. 2011 Jan 27
Hallen L., Klein H., Stoschek C., Wehrmeyer S., Nonhoff U., Ralser M., Wilde J., Röhr C., Schweiger M.R., Zatloukal K., Vingron M., Lehrach H., Konthur Z. and S. Krobitsch. The KRAB-containing zinc-finger transcriptional regulator ZBRK1 activates SCA2 gene transcription through direct interaction with ist gene product ataxin-2. Hum Mol Genet. 2011 Jan 1;20(1):104-14.IF8,
Timmermann BѲ, Kerick MѲ, Röhr C, Fischer A, Isau M, Boerno S, Wunderlich A, Barmeyer C, Seemann P, Koenig J, Lappe M, Kuss AW, Garshasbi M, Bertram L, Trappe K, Werber M, Herrmann BG, Zatloukal K, Lehrach H, Schweiger MR (2010). Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis. PLoS One 5(12):e15661 . Ѳ shared co-first authors
Timmermann BѲ, Kerick MѲ, Röhr C, Fischer A, Isau M, Boerno S, Wunderlich A, Barmeyer C, Seemann P, Koenig J, Lappe M, Kuss AW, Garshasbi M, Bertram L, Trappe K, Werber M, Herrmann BG, Zatloukal K, Lehrach H, Schweiger MR (2010). Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis. PLoS One 5(12):e15661 . Ѳ shared co-first authors
Krawitz PMѲ, Schweiger MRѲ, Rödelsperger C, Isau M, Fischer A, Dahl A, Jonske de Condor B, Kölsch U, Meisel C, Kinoshita T, Murakami Z, Hecht J, Brunner H, Meinecke P, Horn D, Mundlos S, Robinson PN (2010). Identity-by-Descent Filtering of Exome Sequence Data identifies PIGV mutations in Hyperphosphatasia Mental Retardation (HPMR) syndrome. Nat Genetics 42(10):827-9. Ѳ shared co-first authors.
Boerno S.T., Grimm C., Lehrach H. and M.R. Schweiger. Next Generation Sequencing Technologies for DNA Methylation Analyses in Cancer Genomics. Epigenomics 2010 April; 2(2): 199-209
Schweiger M.R., Kerick M., Timmermann B., Albrecht M.W., Borodina T., Parkhomchuk D., Zatloukal K. and H. Lehrach. Genome - wide Massively Parallel Sequencing of Formaldehyde Fixed - Paraffin Embedded (FFPE) Tumor Tissues for Copy-Number- and Mutation-Analysis. PLoS ONE 2009 May ;4(5):e5548
Matthias O., Smith J.A., Schweiger M.R., Robbins D., Powell M.C., You J. and P.M. Howley. Cell type specific transcriptional activities among different papillomavirus long control regions and their regulation by E2. Virology. 2009 Dec 20;395(2):161-71
Gang Z., Schweiger M.R., Martinez-Noel G., Zheng L., Smith J.A., Harper J.W., and P.M. Howley. Brd4 Regulation of Papillomavirus E2 Protein Stability. J Virol. 2009 Sep;83(17):8683-92
Schweiger M.R. Ѳ, Ottinger M. Ѳ, You J., and P.M. Howley. Brd4-independent transcriptional repression function of the papillomavirus e2 proteins. J Virol. 2007 Sep;81(18):9612-22. Ѳ shared co- first authors
Schweiger M.R., You J., and P.M. Howley. Bromodomain Protein 4 Mediates the Papillomavirus E2 Transcriptional Activation Function. J Virol.2006 May;80(9):4276-85
You J., Schweiger M.R. and P.M. Howley. Inhibition of E2 binding to Brd4 enhances viral genome loss and phenotypic reversion of bovine papillomavirus-transformed cells. J Virol.2005 Dec;79(23):14956-61
Blechschmidt K., Schweiger M.R., Wertz K., Poulson R., Christensen H.-M., Rosenthal A., Lehrach H. and M.-L. Yaspo. The mouse AIRE gene: Comparative genomic sequencing, gene organisation and expression. Genome Res 1999; 9:158-66
Publikationen in Laborjournalen
Schweiger MR (2010) PREDICT – a systems biology approach to pre-clinical testing in cancer. BioTOPics 39:14.
Übertragung von Hochdurchsatz-Sequenzierungsdaten in den klinischen Alltag (‚translational cancer research‘). GenomXpress 2.11, 2011 Michal-Ruth Schweiger
Kerick M., Timmermann B. and M.R.Schweiger. Hochdurchsatz-Sequenzierungen von gefrorenem und in Paraffin eingebettetem Tumor- und Normalgewebe. Der Pathologe 8/2010
Dahl A., Mertes F., Marchfelder U., Boerno S., Fischer A., Schweiger M. und H. Lehrach. Bewertung der SOLiD-Sequenzierungsplattform aus Nutzerperspektive. Laborwelt Nr 1/2010-11.Jahrgang, Seite 8-10
Schweiger M.R. and H. Lehrach. From Bench to Bedside: New Technologies for Cancer Diagnosis and Treatment. Journal of International Biotechnology Law. 2008 April;5(2):82-84,
Books and book chapters:
Martin Kerick, Axel Fischer and Michal R.Schweiger. Chapter 9: Generation and Analysis of Genome-Wide DNA Methylation Maps in ‘Bioinformatics for High Throughput Sequencing’, Springer 2012
Michal R.Schweiger and B.Timmermann. Chapter 11: Genomics and cancer risk assessment in ‚Cancer Risk Assessment’, Wiley-VCH 2011,
Lange B.M., Schweiger M.R. and H.Lehrach. ‘Cancer Systems Biology, Bioinformatics and Medicine: Research and Clinical Applications’ Chapter 4: ‘Global molecular and cellular measurement technologies’, F.Marcus and A.Cesario, editors. Springer 2010
Monica Hirsch-Kauffmann, Manfred Schweiger, Michal R. Schweiger. ‚Biologie und molekulare Medizin für Mediziner und Naturwissenschaftler‘: Thieme Verlag, 7., Aufl. 2009, 420 S.,