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Tomasz Zemojtel
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Dr. sc. hum.
Dipl. Ing. (TU) Computer
Science
Max Planck Institute for Molecular
Genetics
Ihnestr. 73
14195 Berlin, Germany
Phone: + 49 30 8413-1170
Fax: + 49 30 8413-1152
Email: zemojtel@molgen.mpg.de
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Research interests
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Genetic diagnostics
§ Inherited
diseases
§ X-linked and
autosomal recessive intellectual disability and related disorders
§ Applications
of next generation sequencing (NGS) – based diagnostics
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Genomic impact of
transposable elements (TEs) / Evolution
of gene regulatory elements
§ TEs as seeds
spreading transcription factor binding sites
§ Exonization
of TEs
§ Alternative
promoters within sequences of TE
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Secondary
interests
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Small G-proteins
·
Nitric Oxide signaling pathway
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Curriculum Vitae
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2004.02- Staff Scientist, Max
Planck Institute for Molecular Genetics, Dep. of Computational Molecular
Biology, Berlin, Germany
Prof.
Martin Vingron
2002.06- 2004.01. Assistant
Professor, Univ. of Wuerzburg, Germany, Dep. of Bioinformatics
Prof. Thomas Dandekar, Prof. Joerg
Schultz
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Degrees
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1994-1999 Dipl.
Ing. (M.Sc.) Computer Science and Engineering,
Supervisor:
Prof. Henryk Krawczyk, Faculty of Electronics, Telecommunications and
Informatics, Technical University of Gdansk, Poland
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Publications (h-index: 11)
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27
26
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Zemojtel
T*, Vingron M
p53 binding
sites in transposons
Frontiers in Genetics 2012
Sun
R, Love MI, Zemojtel T, Emde
AK, Chung HR, Vingron M, Haas SA.
Breakpointer:
using local mapping artifacts to support sequence breakpoint discovery
from single-end reads.
Bioinformatics. 2012 Feb 1.
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25
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Zemojtel T*,
Badge R.M.
Active L1s in
human brains.
Science 2011; E-letter:
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24
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Zemojtel T*, Kielbasa SM, Arndt PF, Behrens S, Bourque G,
Vingron M.
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CpG deamination creates transcription factor-binding
sites with high efficiency.
Genome Biol Evol. 2011;3:1304-11.
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23
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Najmabadi H, Hu H,
Garshasbi M, Zemojtel T,
Abedini SS, Chen W, Hosseini M, Behjati F, Haas S, Jamali P, Zecha A,
Mohseni M, Püttmann L, Vahid LN, Jensen C, Moheb LA, Bienek M, Larti F,
Mueller I, Weissmann R, Darvish H, Wrogemann K, Hadavi V, Lipkowitz B,
Esmaeeli-Nieh S, Wieczorek D, Kariminejad R, Firouzabadi SG, Cohen M,
Fattahi Z, Rost I, Mojahedi F, Hertzberg C, Dehghan A, Rajab A, Banavandi
MJ, Hoffer J, Falah M, Musante L, Kalscheuer V, Ullmann R, Kuss AW,
Tzschach A, Kahrizi K, Ropers HH.
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Deep sequencing reveals 50 novel genes for recessive
cognitive disorders.
Nature.
2011; 478(7367):57-63.
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22
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Kolanczyk M, Mautner
V, Kossler N, Nguyen R, Kühnisch J, Zemojtel
T, Jamsheer A, Wegener E, Thurisch B, Tinschert S, Holtkamp N, Park
SJ, Birch P, Kendler D, Harder A, Mundlos S, Kluwe L.
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MIA is a potential biomarker for tumour load in
neurofibromatosis type 1.
BMC Med.
2011; 9:82. PMID:21726432
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21
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Lin S, Haas S, Zemojtel
T, Xiao P, Vingron M, Li R.
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Genome-wide
comparison of cyanobacterial transposable elements, potential genetic
diversity indicators.
Gene. 2011 Mar 1;473(2):139-49. PMID:21156198
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Kolanczyk M, Pech M, Zemojtel T*, Yamamoto H, Mikula
I, Calvaruso MA, van den Brand M, Richter R, Fischer B, Ritz A, Kossler
N, Thurisch B, Spoerle R, Smeitink J, Kornak U, Chan D, Vingron M,
Martasek P, Lightowlers RN, Nijtmans L, Schuelke M, Nierhaus KH, Mundlos
S
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NOA1 is an
essential GTPase required for mitochondrial protein synthesis.
Mol
Biol Cell. 2011 Jan
1;22(1):1-11.
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19
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Zemojtel T*, Duchniewicz M, Zhang Z, Paluch T, Luz H,
Penzkofer T, Scheele JS, Zwartkruis FJ.
Retrotransposition
and mutation events yield Rap1 GTPases with differential signalling
capacity.
BMC Evol Biol. 2010;10:55. PMID:20170508
Scheele
JS, Kolanczyk M, Gantert M, Zemojtel
T, Dorn A, Sykes DP, Möbest DC, Kamps MP, Räpple D, Duchniewicz M.
The Spt-Ada-Gcn5-acetyltransferase complex interaction
motif of E2a is essential for a subset of transcriptional and oncogenic
properties of E2a-Pbx1.
Leuk Lymphoma. 2009; 50(5):816-28. PMID: 19399691
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Jürgens
AS, Kolanczyk M, Moebest DC, Zemojtel
T, Lichtenauer U, Duchniewicz M, Gantert MP, Hecht J, Hattenhorst U,
Burdach S, Dorn A, Kamps MP, Beuschlein F, Räpple D, Scheele JS.
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PBX1 is dispensable for
neural commitment of RA-treated murine ES cells.
In Vitro Cell Dev Biol Anim. 2009; 45(5-6):252-63. PMID: 19148706
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Raepple D, von Lintig F, Zemojtel T, Duchniewicz M, Jung
A, Lübbert M, Boss GR, Scheele JS.
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Determination of Ras-GTP
and Ras-GDP in patients with acute myelogenous leukemia (AML),
myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia
(JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma:
assessment of mutational and indirect activation.
Ann Hematol. 2009; 88(4):319-24. PMID: 18784923
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Lichtenauer
UD, Duchniewicz M, Kolanczyk M, Hoeflich A, Hahner S, Else T, Bicknell
AB, Zemojtel T*, Stallings
NR, Schulte DM, Kamps MP, Hammer GD, Scheele JS, Beuschlein F.
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Pre-B-cell transcription
factor 1 and steroidogenic factor 1 synergistically regulate
adrenocortical growth and steroidogenesis.
Endocrinology 2007; 148(2):693-704. PMID: 17082260
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Zemojtel T*, Fröhlich A,
Palmieri MC, Kolanczyk M, Mikula I, Wyrwicz LS, Wanker EE, Mundlos S,
Vingron M, Martasek P, Durner J.
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Plant nitric oxide
synthase: a never-ending story?
Trends in Plant Science 2006; 11(11):524-5. PMID: 17030145
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9
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Zemojtel T* and Kolanczyk M,
Kossler N, Stricker S, Lurz R, Mikula I, Duchniewicz M, Schuelke M,
Ghafourifar P, Martasek P, Vingron M, Mundlos S.
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Mammalian mitochondrial
nitric oxide synthase: characterization of a novel candidate.
FEBS Lett. 2006 Jan 23;580(2):455-62. PMID: 16380119
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Ginalski K and Zemojtel T*.
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ECEPE proteins: a novel
family of eukaryotic cysteine proteinases.
Trends Biochem Sci. 2004; 29(10):524-6. PMID: 15450606
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*corresponding author
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