Introduction to DNA methylation and its impact on gene regulation

In mammals there are various mechanisms for regulating gene expression. One of these mechanisms is the utilization of methyl groups attached to the cytosine residues of the DNA. Whether or not a gene is expressed can depend on the fact whether a given cytosine site is methylated. In the context of this lecture/seminar the concept of DNA methylation as regulatory mechanism will be introduced and studied by focussing on the following aspects:

Evolution;

Transcriptional regulation;

Imprinting;

chromosomal inactivation;

Impact on diseases.

Based on recent papers focussing on one of the aspects above seminar talks are expected to be given by participants.

[Credits] [Literature] [Syllabus]

Lecturer: Christine Steinhoff

Lectures: November: Thursday: 10:00-12:30

Seminar: Depending on the number of participants, two Weekend Seminar blocks TBA

Location: SR 331, Ihnestr 63-73

KVV

Web page

Contacts: steinhof@molgen.mpg.de

This class involves mandatory attendance of all lectures and seminars. Based on recent papers focussing on one epigenetic aspect seminar talks are expected to be given by participants.

Students will earn 4 credit points for regular attendance and successful seminar talk (including handout and presentation of the intended talk before the seminartalk).

Literature

Slides from 25.10.2007 (ppt)

Syllabus