Research Profile: Eike Staub

Research Interests

• protein sequence analysis, in particular the discovery of genetically mobile protein domains
• evolutionary history and function of the nucleolus
• early events in the evolution of eukaryotes
• eukaryotic phylogeny
• use of alternative sequence-related traits for phylogenetic reconstruction
• genetic changes leading to cancer
• genetic changes leading to non-channel epilepsies

Publications

Alldinger, I., Dittert, D., Peiper, M., Fusco, A., Chiappetta, G., Staub, E., Lohr, M., Jesnowski, R., Baretton, G., Ockert, D. et al. (2005) Gene Expression Analysis of Pancreatic Cell Lines Reveals Genes Overexpressed in Pancreatic Cancer. Pancreatology, 5, 370-379.

Kasper, G., Vogel, A., Klaman, I., Grone, J., Petersen, I., Weber, B., Castanos-Velez, E., Staub, E. and Mennerich, D. (2005) The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression. Cancer Lett, 224, 93-103.

Meinel, T., Krause, A., Luz, H., Vingron, M. and Staub, E. (2005) The SYSTERS protein family database in 2005. Nucleic Acids Res, 33, D226-D229.

Staub, E., Rosenthal, A. and Hinzmann, B. (2004) Systematic identification of immunoreceptor tyrosine-based inhibitory motifs in the human proteome. Cell Signal, 16, 435-456.

Staub, E., Fiziev, P., Rosenthal, A. and Hinzmann, B. (2004) Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire. Bioessays, 26, 567-581.

Staub, E., Fiziev, P., Rosenthal, A. and Hinzmann, B. (2004) The nucleolar proteome and the (endosymbiotic) origin of the nucleus - Response. Bioessays, 26, 1145-1147.

Himmelfarb, M., Klopocki, E., Grube, S., Staub, E., Klaman, I., Hinzmann, B., Kristiansen, G., Rosenthal, A., Durst, M. and Dahl, E. (2004) ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer. Cancer Lett, 204, 69-77.

Liepinsh, E., Barbals, R., Dahl, E., Sharipo, A., Staub, E. and Otting, G. (2003) The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition. J Mol Biol, 332, 1155-1163.

Grutzmann, R., Pilarsky, C., Staub, E., Schmitt, A.O., Foerder, M., Specht, T., Hinzmann, B., Dahl, E., Alldinger, I., Rosenthal, A. et al. (2003) Systematic isolation of genes differentially expressed in normal and cancerous tissue of the pancreas. Pancreatology, 3, 169-178.

Grutzmann, R., Foerder, M., Alldinger, I., Staub, E., Brummendorf, T., Ropcke, S., Li, X.Z., Kristiansen, G., Jesnowski, R., Sipos, B. et al. (2003) Gene expression profiles of microdissected pancreatic ductal adenocarcinoma. Virchows Arch, 443, 508-517.

Staub, E., Mennerich, D. and Rosenthal, A. (2002) The Spin/Ssty repeat: a new motif identified in proteins involved in vertebrate development from gamete to embryo. Genome Biol, 3, RESEARCH0003.

Staub, E., Perez-Tur, J., Siebert, R., Nobile, C., Moschonas, N.K., Deloukas, P. and Hinzmann, B. (2002) The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders. Trends Biochem Sci, 27, 441-444.

Staub, E., Hinzmann, B. and Rosenthal, A. (2002) A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family. Febs Lett, 527, 114-118.

Reczko, M., Fiziev, P., Staub, E. and Hatzigeorgiou, A. (2002) Finding signal peptides in human protein sequences using recurrent neural networks. Lect Notes Comput Sc, 2452, 60-67.

Morante-Redolat, J.M., Gorostidi-Pagola, A., Piquer-Sirerol, S., Saenz, A., Poza, J.J., Galan, J., Gesk, S., Sarafidou, T., Mautner, V.F., Binelli, S. et al. (2002) Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy. Hum Mol Genet, 11, 1119-1127.

Kasper, G., Taudien, S., Staub, E., Mennerich, D., Rieder, M., Hinzmann, B., Dahl, E., Schwidetzky, U., Rosenthal, A. and Rump, A. (2002) Different structural organization of the encephalopsin gene in man and mouse. Gene, 295, 27-32.

Staub, E., Dahl, E. and Rosenthal, A. (2001) The DAPIN family: a novel domain links apoptotic and interferon response proteins. Trends Biochem Sci, 26, 83-85.

PhD Thesis

Short CV

• Sep-2003 until today
  Scientist at the Computational Molecular Biology Department at the Max-Planck-Institute for Molecular Genetics.
• Mar-2002 until June-2003
  Scientist in the Bioinformatics division at the cancer research company metaGen Pharmaceuticals in Berlin.
• Sep-1999 until Feb-2002
  PhD candidate in the Bioinformatics division of metaGen Pharmaceuticals in Berlin.
• July-1999
  University degree (Dipl. Biotechnol.) in Biotechnology at the Technical University Braunschweig
• Sep-1998 until April-1999
  Final thesis (Diplomarbeit) in the Prostate Cancer Division at metaGen Pharmaceuticals in Berlin on "Expression analysis of prostate cancer cell lines using cDNA arrays"
• 1996
  Intermediate thesis (Studienarbeit) at the University of Glasgow in the Institute of Biomedical and Life Sciences (IBLS) on "the beta-sheet properties of amino acids" in the group of James E. Milner-White
• Oct-1993
  Started to study Biotechnology at the Technical University Braunschweig
• Sep-1992 until Sep-1993
  Civil service at the "Beschuetzende Werkstaetten" in Osnabrück
• June-1992
  Abitur at the Ratsgymnasium Osnabrueck
• 12-Jul-1972
  Born in Osnabrueck, Germany

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