1994 Diploma in mathematics from the University of Bonn 1999 PhD in biology from the University of Bonn and the German Cancer Research Center, Heidelberg 2001-present Head of the Computational Diagnostics Group at the Max Planck Institute for Molecular Genetics, Berlin Research interests Reverse engineering of complex biological systems Hight throughput intervention data Diagnosis of cancer based on molecular profiles Bioinformatics, Machine Learning and Statistics Publications Annotation-based Distance Measures for Patient Subgroup Discovery in Clinical Microarray Studies Lottaz C, Toedling J, Spang R In Proceedings of the German Conference on Bioinformatics, Tübingen, Germany, Sep 20-22, 2006 (accepted). OrderedList - a Bioconductor Package for Detecting Similarity in Ordered Gene Lists Lottaz C, Yang X, Scheid s, Spang R Bioinformatics, to be published Automated In-Silico Detection of Cell Populations in Flow Cytometry Readouts and its Application to Leukemia Disease Monitoring Toedling J, Rhein P, Ratei R, Karawajew L, Spang R. BMC Bioinformatics, 7:282, 2006 Expression of late cell cycle genes and an increased proliferative capacity characterize very early relapse of childhood acute lymphoblastic leukemia Kirschner-Schwabe R, Lottaz C, Toedling J, Rhein P, Karawajew L, Eckert C, von Stackelberg A, Ungethüm U, Henze G, Kostka D, Spang R, Hagemeier C, Seeger K. Clinical Cancer Research, to be published. (Review) Patient Classification Lottaz C Kostka D Spang R In: Bioinformatics - From Genomes to Therapies. T. Lengauer (Ed), Wiley-VCH, to be published. Permutation filtering: A novel concept for significance analysis of large-scale genomic dat Scheid S, Spang R In: Apostolico A, Guerra C, Istrail S, Pevzner P, and Waterman M (Eds.): Research in Computational Molecular Biology: 10th Annual International Conference, Proceedings of RECOMB 2006, Venice, Italy, April 2-5, 2006, Lecture Notes in Computer Science vol. 3909, Springer, Heidelberg, pp. 338-347 (RECOMB 2006). A biological definition of Burkitt lymphoma derived from transcriptional and genomic profiling Hummel, Bentink, Berger, Klapper, Wessendorf, Barth, Bernd, Cogliatti, Dierlamm, Feller, Hansmann, Haralambieva, Harder, Hasenclever, Kühn, Lenze, Lichter, Martin-Subero, Möller, Müller-Hermelink, Ott, Parwaresch, Pott, Rosenwald, Rosolowski, Schwaenen, Stürzenhofecker, Szcepanowski, Trautmann, Wacker, Spang , Löffler, Trümper, Stein, Siebert New England Journal of Medicine 354(23), 2419-30, 2006 Similarities of ordered gene lists Yang X, Bentink S, Scheid S, Spang R In: Journal of Bioinformatics and Computational Biology (accepted). (Review) Computational diagnostics Spang R, Markowetz F In: Ganten and Ruckpaul (eds.), Encyclopedic Reference of Genomics and Proteomics, Springer (accepted). Non-transcriptional pathway features reconstructed from secondary effects of RNA interference Markowetz F, Bloch J, Spang R Bioinformatics 2005 21: 4026-4032. [ PMID: 16159925 | doi:10.1093/bioinformatics/bti662 ] (Review) Microarray data analysis: Differential gene expression Scheid S, Spang R In: Ulrike Nuber (ed.), DNA Microarrays, Taylor & Francis Group, UK. ISBN: 0-415-35866-3. [ BIOS ] stam - a Bioconductor compliant R package for structured analysis of microarray data Lottaz C, Spang R BMC Bioinformatics. 2005 Aug 25;6(1):211 [ PMID: 16122395 | doi:10.1186/1471-2105-6-211 ] (Review) Traces of molecular disease mechanisms on microarrays. Lottaz C, Kostka D, Spang R In: Kaufmann (ed.) Methoden in der empirischem Forschung. ISSN 1615-4177, p. 231-236 Detecting common gene expression patterns in multiple cancer outcome entities Yang X, Bentink S, Spang R Biomedical Microdevices, Sep 2005, 7(3):247-251. [ PMID: 16133813 | doi:10.1007/s10544-005-3032-7 ] Molecular diagnosis: classification, model selection, and performance evaluation Markowetz F, Spang R Methods of Information in Medicine 2005, 44: 438-43. [ PMID: 16113770 ] twilight; a Bioconductor package for estimating the local false discovery rate Scheid S, Spang R Bioinformatics 2005 21(12):2921-2922. [ PMID: 15817688 | doi:10.1093/bioinformatics/bti436 ] Molecular Decomposition of Complex Clinical Phenotypes using Biologically Structured Analysis of Microarray Data Lottaz C, Spang R Bioinformatics 2005 21(9):1971-1978. [ PMID: 15677704 | doi:10.1093/bioinformatics/bti292 ] Early diagnostic marker panel determination for microarray based clinical studies Jäger J, Weichenhan D, Ivandic B, Spang R Statistical Applications in Genetics and Molecular Biology: Vol. 4: No. 1, Article 9. [ bepress ] Probabilistic soft interventions in conditional gaussian networks Markowetz F, Grossmann S, Spang R Proc. Tenth International Workshop on Artificial Intelligence and Statistics (AISTATS), Jan. 2005 [ pdf | bib entry | conference website ] A stochastic downhill search algorithm for estimating the local false discovery rate Scheid S, Spang R IEEE Transactions on Computational Biology and Bioinformatics 1(3):98-108, 2004. [ abstract | pdf | notice ] (Review) Vom Biochip zur maßgeschneiderten Therapie Jäger J, Spang R BIOforum 6/2004, pp 50-51 Finding disease specific alterations in the coexpression of genes Kostka D, Spang R Bioinformatics 20(Suppl. 1), 2004: i194-i199 (Proceedings of ISMB 2004). [ PMID: 15262799 | doi:10.1093/bioinformatics/bth909 | erratum ] Differential myocardial gene expression in the development and rescue of murine heart failure Blaxall BC, Spang R, Rockman HA, Koch WJ. Physiol Genomics. 2003 Oct 17;15(2):105-14. [ PMID: 12865503 | Full Text ] Evaluating the Effect of Perturbations in Reconstructing Network Topologies Florian Markowetz and Rainer Spang Proceedings of the 3rd International Workshop on Distributed Statistical Computing [ DSC 2003 ] [ abstract | pdf | bib entry ] A False Discovery Rate Approach to Separate the Score Distributions of Induced and Non-induced Genes Stefanie Scheid and Rainer Spang Proceedings of the 3rd International Workshop on Distributed Statistical Computing [ DSC 2003 ] [ abstract | pdf ] (Review) Diagnostic signatures from microarrays: a bioinformatics concept for personalized medicine Rainer Spang Biosilico Vol. 1, No. 2 May 2003, 64-68 Expression profiling of human idiopathic dilated cardiomyopathy Rafal Grzeskowiak, Henning Witt, Mario Drungowski, Rolf Thermann, Steffen Hennig, Andreas Perrot, Karl J. Osterziel, Dirk Klingbiel, Stefanie Scheid, Rainer Spang, Hans Lehrach, and Patricia Ruiz Cardiovasc Res. 2003 Aug 1;59(2):400-11. [ PMID:12909323 | doi:10.1016/S0008-6363(03)00426-7 ] A Novel Approach to Remote Homology Detection: Jumping Alignments Rainer Spang, Marc Rehmsmeier and Jens Stoye Journal of Computational Biology, Volume 9, Number 5, 747-760, 2002 [ PMID: 12487762 | doi:10.1089/106652702761034172 ] Estimating Amino Acid Substitution Models: A Comparison of Dayhoff's Estimator, the Resolvent Approach and a Maximum Likelihood Method Tobias Müller, Rainer Spang and Martin Vingron Mol. Biol. Evol.19(1), 8-13 2002 [ PMID: 11752185 ] Prediction and uncertainty in the analysis of gene expression profiles Rainer Spang, Carrie Blanchette, Harry Zuzan, Jeffrey R. Marks, Joseph Nevins and Mike West In Silico Biol. 2002;2(3):369-81. [ PMID:12542420 | online publication ] Predicting the clinical status of human breast cancer by using gene expression profiles West M, Blanchette C, Dressman H, Huang E, Ishida S, Rainer Spang, Zuzan H, Olson JA Jr, Marks JR, Nevins JR. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11462-7 [ PMID: 11562467 | doi:10.1073/pnas.201162998 ] Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis Ishida S, Huang E, Zuzan H, Rainer Spang, Leone G, West M, Nevins J.R. Mol Cell Biol. 2001 Jul;21(14):4684-99 [ PMID: 11416145 | doi:10.1128/MCB.21.14.4684-4699.2001 ] Limits of homology detection by pairwise sequence comparison Rainer Spang and Martin Vingron Bioinformatics 2001, 17,4, 338-342 [ PMID: 11301302 ] Sequence Database Search Using Jumping Alignments Rainer Spang, Marc Rehmsmeier and Jens Stoye Proceedings of the Eighth International Conference on Intelligent systems for Molecular Biology, AAAI Press, Menlo Park, CA, 2000, 367-375. [ PMID: 10977097 | pdf ] Statistics of Large Scale Sequence Searching Rainer Spang and Martin Vingron Bioinformatics, 1998, 14, 279-284 [ pdf ] << top

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