| Wendeler
M. W., Jung R., Himmelbauer H., Gessner R. (2006). Unique gene
structure and paralogy define the 7D-cadherin family. Cellular and
Molecular Life Sciences, in press. Abstract: Cadherins are Ca(2+)-dependent
transmembrane glycoproteins crucial for
cell-cell adhesion in vertebrates and invertebrates. Classification of
this superfamily due to their phylogenetic relationship is currently
restricted to three major subfamilies: classical, desmosomal and
protocadherins. Here we report evidence for a common phylogenetic
origin of the kidney-specific Ksp- (Cdh16)
and the intestine-specific
LI-cadherin (Cdh17). Both
genes consist of 18 exons and the positions
of their exon-intron boundaries as well as their intron phases are
perfectly conserved. We found an extensive paralogy of more than 40
megabases in mammals as well as teleost fish species encompassing the
Ksp- and LI-cadherin genes. A comparable paralogy was not detected for
other cadherin gene loci. These findings suggest that the Ksp- and
LI-cadherin genes originated by chromosomal duplication early during
vertebrate evolution and support our assumption that both proteins are
paralogues within a separate cadherin family that we have termed
7D-cadherins.
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| View on screen: |
| 7D_CadherineEdited.txt |
| Atp6v0d1and2Edit.txt |
| Calbindin1and2Edit.txt |
| Cbfa2t1h_and3hEdit.txt |
| pdp_1und2Edit.txt |
| Gem_RadEdit.txt |
| CdhFamiliesEdited.txt |
| CdhFamily2.txt |
| Download figures and tables: |
| FigsS1and2.doc |
| Wendeler_CMLS_TableS1.doc |
| Wendeler_CMLS_TableS2.doc |