Molecular Embryology

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	Molecular Embryology

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- 2011 –

Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development.

Göke J, Jung M, Behrens S, Chavez L, O'Keeffe S, Timmermann B, Lehrach H, Adjaye J, Vingron M.

PLoS Comput Biol. 2011 Dec;7(12):e1002304. Epub 2011 Dec 22.

PMID: 22215994

Mitochondrial-Associated Cell Death Mechanisms Are Reset to an Embryonic-Like State in Aged Donor-Derived iPS Cells Harboring Chromosomal Aberrations.

Prigione A, Hossini AM, Lichtner B, Serin A, Fauler B, Megges M, Lurz R, Lehrach H, Makrantonaki E, Zouboulis CC, Adjaye J.

PLoS One. 2011;6(11):e27352. Epub 2011 Nov 14.

PMID: 22110631

Activation of pluripotency-associated genes in mouse embryonic fibroblasts by non-viral transfection with in vitro-derived mRNAs encoding Oct4, Sox2, Klf4 and cMyc.

Tavernier G, Wolfrum K, Demeester J, De Smedt SC, Adjaye J, Rejman J.

Biomaterials. 2012 Jan;33(2):412-7. Epub 2011 Oct 10.

PMID: 21993235

Quantitative Real-Time PCR-Based Analysis of Gene Expression.

Jozefczuk J, Adjaye J.

Methods Enzymol. 2011;500:99-109.

PMID: 21943894

A strand-specific library preparation protocol for RNA sequencing.

Borodina T, Adjaye J, Sultan M.

Methods Enzymol. 2011;500:79-98.

PMID: 21943893

Molecular Insights into Reprogramming-Initiation Events Mediated by the OSKM Gene Regulatory Network.

Mah N, Wang Y, Liao MC, Prigione A, Jozefczuk J, Lichtner B, Wolfrum K, Haltmeier M, Flöttmann M, Schaefer M, Hahn A, Mrowka R, Klipp E, Andrade-Navarro MA, Adjaye J.

PLoS One. 2011;6(8):e24351. Epub 2011 Aug 31.

PMID: 21909390

Human iPSCs Harbor Homoplasmic and Heteroplasmic Mitochondrial DNA Mutations While Maintaining hESC-Like Metabolic Reprogramming.

Prigione A, Lichtner B, Kuhl H, Struys EA, Wamelink M, Lehrach H, Ralser M, Timmermann B, Adjaye J.

Stem Cells. 2011 Jul 5.

doi: 10.1002/stem.683. [Epub ahead of print]

PMID: 21732474

Gatekeeper of pluripotency: A common Oct4 transcriptional network operates in mouse eggs and embryonic stem cells.

Zuccotti M, Merico V, Bellone M, Mulas F, Sacchi L, Rebuzzini P, Prigione A, Redi CA, Bellazzi R, Adjaye J, Garagna S.

BMC Genomics. 2011 Jul 5;12(1):345. [Epub ahead of print]

PMID: 21729306

Network-Like Impact of MicroRNAs on Neuronal Lineage Differentiation of Unrestricted Somatic Stem Cells from Human Cord Blood.

Iwaniuk KM, Schira J, Weinhold S, Jung M, Adjaye J, Müller HW, Wernet P, Trompeter HI.

Stem Cells Dev. 2011 Mar 8. [Epub ahead of print]

PMID: 21067317

Comparative Analysis of Human Embryonic Stem Cell and Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells Reveals Current Drawbacks and Possible Strategies for Improved Differentiation.

Jozefczuk J, Prigione A, Chavez L, Adjaye J.

Stem Cells Dev. 2011 Jan 24. [Epub ahead of print]

PMID: 21162674

- 2010 -

An ES-like pluripotent state in FGF-dependent murine iPS cells.

Di Stefano B, Buecker C, Ungaro F, Prigione A, Chen HH, Welling M, Eijpe M, Mostoslavsky G, Tesar P, Adjaye J, Geijsen N, Broccoli V.

PLoS One. 2010 Dec 30;5(12):e16092.

PMID: 21209851 [PubMed - in process]

Bioinformatics in aging research: a workshop report.

Fuellen G, Adjaye J, de Grey A, Lepperdinger G, de Magalhães JP, Sühnel J, Wipat A.

Rejuvenation Res. 2010 Dec;13(6):763-7. Epub 2011 Jan 4.

PMID: 21204651 [PubMed - in process]

A Cyclic AMP Analog, 8-Br-cAMP, Enhances the Induction of Pluripotency in Human Fibroblast Cells.

Wang Y, Adjaye J.

Stem Cell Rev. 2010 Dec 1. [Epub ahead of print]

PMID: 21120637 [PubMed - as supplied by publisher]

The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells.

Wolfrum K, Wang Y, Prigione A, Sperling K, Lehrach H, Adjaye J.

PLoS One. 2010 Oct 29;5(10):e13703.

PMID: 21060825 [PubMed - indexed for MEDLINE]

Skin and brain age together: The role of hormones in the ageing process.

Makrantonaki E, Schönknecht P, Hossini AM, Kaiser E, Katsouli MM, Adjaye J, Schröder J, Zouboulis CC.

Exp Gerontol. 2010 Oct;45(10):801-13. Epub 2010 Aug 16. Review.

PMID: 20719245 [PubMed - indexed for MEDLINE]

Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage.

Chavez L, Jozefczuk J, Grimm C, Dietrich J, Timmermann B, Lehrach H, Herwig R, Adjaye J.

Genome Res. 2010 Oct;20(10):1441-50. Epub 2010 Aug 27.

PMID: 20802089 [PubMed - indexed for MEDLINE]

Molecular characterization of cultured adult human liver progenitor cells.

Jozefczuk J, Stachelscheid H, Chavez L, Herwig R, Lehrach H, Zeilinger K, Gerlach JC, Adjaye J.

Tissue Eng Part C Methods. 2010 Oct;16(5):821-34.

PMID: 19874131 [PubMed - indexed for MEDLINE]

Governing cell lineage formation in cloned mouse embryos.

Balbach ST, Esteves TC, Brink T, Gentile L, McLaughlin KJ, Adjaye JA, Boiani M.

Dev Biol. 2010 Jul 1;343(1-2):71-83. Epub 2010 Apr 22.

PMID: 20417198 [PubMed - indexed for MEDLINE]

A transcriptional roadmap to the induction of pluripotency in somatic cells.

Wang Y, Mah N, Prigione A, Wolfrum K, Andrade-Navarro MA, Adjaye J.

Stem Cell Rev. 2010 Jun;6(2):282-96. Review.

PMID: 20336394 [PubMed - indexed for MEDLINE]

A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells.

Jung M, Peterson H, Chavez L, Kahlem P, Lehrach H, Vilo J, Adjaye J.

PLoS One. 2010 May 21;5(5):e10709.

PMID: 20505756 [PubMed - indexed for MEDLINE]

Cancer stem cells in solid tumors: elusive or illusive?

Welte Y, Adjaye J, Lehrach HR, Regenbrecht CR.

Cell Commun Signal. 2010 May 11;8(1):6.

PMID: 20459772 [PubMed - in process]

The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells.

Prigione A, Fauler B, Lurz R, Lehrach H, Adjaye J.

Stem Cells. 2010 Apr;28(4):721-33.

PMID: 20201066 [PubMed - indexed for MEDLINE]

Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells.

Prigione A, Adjaye J.

Int J Dev Biol. 2010;54(11-12):1729-41.

PMID: 21305470 [PubMed - in process]

- 2009 -

Comparative proteome and transcriptome analyses of embryonic stem cells during embryoid body-based differentiation.

Fathi A, Pakzad M, Taei A, Brink TC, Pirhaji L, Ruiz G, Sharif Tabe Bordbar M, Gourabi H, Adjaye J, Baharvand H, Salekdeh GH.

Proteomics. 2009 Nov;9(21):4859-70.

PMID: 19862760 [PubMed - indexed for MEDLINE]

Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging.

Brink TC, Demetrius L, Lehrach H, Adjaye J.

Biogerontology. 2009 Oct;10(5):549-64. Epub 2008 Nov 23.

PMID: 19031007 [PubMed - indexed for MEDLINE]

Oct-4 regulates the expression of Stella and Foxj2 at the Nanog locus: implications for the developmental competence of mouse oocytes.

Zuccotti M, Merico V, Sacchi L, Bellone M, Brink TC, Stefanelli M, Redi CA, Bellazzi R, Adjaye J, Garagna S.

Hum Reprod. 2009 Sep;24(9):2225-37. Epub 2009 May 28.

PMID: 19477878 [PubMed - indexed for MEDLINE]

In silico identification of a core regulatory network of OCT4 in human embryonic stem cells using an integrated approach.

Chavez L, Bais AS, Vingron M, Lehrach H, Adjaye J, Herwig R.

BMC Genomics. 2009 Jul 15;10:314.

PMID: 19604364 [PubMed - indexed for MEDLINE]

Activation of the immune response is a key feature of aging in mice.

Brink TC, Regenbrecht C, Demetrius L, Lehrach H, Adjaye J.

Biogerontology. 2009 Mar 3. [Epub ahead of print]

PMID: 19255868 [PubMed - as supplied by publisher]

Role of Oct-4 during acquisition of developmental competence in mouse oocyte.

Zuccotti M, Merico V, Redi CA, Bellazzi R, Adjaye J, Garagna S.

Reprod Biomed Online. 2009;19 Suppl 3:57-62. Review.

PMID: 20034424 [PubMed - indexed for MEDLINE]

Genome-wide expression profiling reveals distinct clusters of transcriptional regulation during bovine preimplantation development in vivo.

Kues WA, Sudheer S, Herrmann D, Carnwath JW, Havlicek V, Besenfelder U, Lehrach H, Adjaye J, Niemann H.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19768-73. Epub 2008 Dec 8. Erratum in: Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1679.

PMID: 19064908 [PubMed - indexed for MEDLINE]

1. Pluripotency and differentiation in embryos and stem cells.

Adjaye JA, Byskov AG, Cibelli JB, De Maria R, Minger S, Sampaolesi M, Testa G, Verfaillie C, Zernicka-Goetz M, Schöler H, Boiani M, Crosetto N, Redi CA.

Int J Dev Biol. 2008;52(7):801-9. PMID: 18956312 Related articlesFree article

2.The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines.

Regenbrecht CR, Jung M, Lehrach H, Adjaye J.

BMC Med Genomics. 2008 Oct 10;1:49.PMID: 18847459 Related articlesFree article

3. Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes.

Zuccotti M, Merico V, Sacchi L, Bellone M, Brink TC, Bellazzi R, Stefanelli M, Redi CA, Garagna S, Adjaye J.

BMC Dev Biol. 2008 Oct 6;8:97.PMID: 18837968 Related articlesFree article

4.Human skin stem cells and the ageing process.

Zouboulis CC, Adjaye J, Akamatsu H, Moe-Behrens G, Niemann C.

Exp Gerontol. 2008 Nov;43(11):986-97. Epub 2008 Sep 9. Review.PMID: 18809487 Related articles

5.Stemming cancer: functional genomics of cancer stem cells in solid tumors.

Regenbrecht CR, Lehrach H, Adjaye J.

Stem Cell Rev. 2008 Dec;4(4):319-28. Review.PMID: 18561035 Related articlesFree article

6.Control of early fate decisions in human ES cells by distinct states of TGFbeta pathway activity.

Greber B, Lehrach H, Adjaye J.

Stem Cells Dev. 2008 Dec;17(6):1065-77.PMID: 18393632 Related articles

7. The origins of human embryonic stem cells: a biological conundrum.

Brink TC, Sudheer S, Janke D, Jagodzinska J, Jung M, Adjaye J.

Cells Tissues Organs. 2008;188(1-2):9-22. Epub 2007 Dec 20.PMID: 18160822 Related articles

1. Generation of amplified RNAs and cDNA libraries from single mammalian cells.

Methods Mol Med. 2007;132:117-24.PMID: 17876080 Related articles

2. Functional genomics of human pre-implantation development.

Sudheer S, Adjaye J.

Brief Funct Genomic Proteomic. 2007 Jun;6(2):120-32. Epub 2007 Jul 31. Review.PMID: 17670767 Related articlesFree article

3. Conserved molecular portraits of bovine and human blastocysts as a consequence of the transition from maternal to embryonic control of gene expression.

Adjaye J, Herwig R, Brink TC, Herrmann D, Greber B, Sudheer S, Groth D, Carnwath JW, Lehrach H, Niemann H.

Physiol Genomics. 2007 Oct 22;31(2):315-27. Epub 2007 Jun 26.PMID: 17595343 Related articlesFree article

4. Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal.

Greber B, Lehrach H, Adjaye J.

BMC Dev Biol. 2007 May 16;7:46.PMID: 17506876 Related articlesFree article

5. Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells.

Babaie Y, Herwig R, Greber B, Brink TC, Wruck W, Groth D, Lehrach H, Burdon T, Adjaye J.

Stem Cells. 2007 Feb;25(2):500-10. Epub 2006 Oct 26.PMID: 17068183 Related articlesFree article

6. Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal.

Greber B, Lehrach H, Adjaye J.

Stem Cells. 2007 Feb;25(2):455-64. Epub 2006 Oct 12.PMID: 17038665 Related articlesFree article

1. Aging of human sebocytes in vitro induced by exposure to a defined hormone environment.

Makrantonaki E, Adjaye J, Herwig R, Brink TC, Groth D, Hultschig C, Lehrach H, Zouboulis CC.

Dermatology. 2006;213(3):262-3. No abstract available. PMID: 17033188 Related articles

2. Age-specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro.

Makrantonaki E, Adjaye J, Herwig R, Brink TC, Groth D, Hultschig C, Lehrach H, Zouboulis CC.

Aging Cell. 2006 Aug;5(4):331-44. Epub 2006 Jun 29.PMID: 16805856 Related articles

1. Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin.

Papakonstantinou E, Aletras AJ, Glass E, Tsogas P, Dionyssopoulos A, Adjaye J, Fimmel S, Gouvousis P, Herwig R, Lehrach H, Zouboulis CC, Karakiulakis G.

J Invest Dermatol. 2005 Oct;125(4):673-84.PMID: 16185265 Related articlesFree article

2. Primary differentiation in the human blastocyst: comparative molecular portraits of inner cell mass and trophectoderm cells.

Adjaye J, Huntriss J, Herwig R, BenKahla A, Brink TC, Wierling C, Hultschig C, Groth D, Yaspo ML, Picton HM, Gosden RG, Lehrach H.

Stem Cells. 2005 Nov-Dec;23(10):1514-25. Epub 2005 Aug 4.PMID: 16081659 Related articlesFree article

3. Whole-genome approaches for large-scale gene identification and expression analysis in mammalian preimplantation embryos.

Reprod Fertil Dev. 2005;17(1-2):37-45. Review.PMID: 15745630 Related articles

1. Cross-species hybridisation of human and bovine orthologous genes on high density cDNA microarrays.

Adjaye J, Herwig R, Herrmann D, Wruck W, Benkahla A, Brink TC, Nowak M, Carnwath JW, Hultschig C, Niemann H, Lehrach H.

BMC Genomics. 2004 Oct 28;5(1):83.PMID: 15511299 Related articlesFree article

2002 - 1993

1. A source for expression profiling in single preimplantation bovine embryos.

Ponsuksili S, Wimmers K, Adjaye J, Schellander K.

Theriogenology. 2002 Apr 1;57(6):1611-24.PMID: 12035973 Related articles

2. Molecular approaches to the study of gene expression during human preimplantation development.

Hurley J, Huntriss J, Adjaye J.

Hum Fertil (Camb). 2000;3(1):48-51.PMID: 11844354 Related articles

3. Cloning of HOXD1 from unfertilised human oocytes and expression analyses during murine oogenesis and embryogenesis.

Pitera JE, Milla PJ, Scambler P, Adjaye J.

Mech Dev. 2001 Dec;109(2):377-81.PMID: 11731253 Related articles

4. Expression of homeobox-containing genes in cDNA libraries derived from cattle oocytes and preimplantation stage embryo.

Ponsuksili S, Wimmers K, Adjaye J, Schellander K.

Mol Reprod Dev. 2001 Nov;60(3):297-301.PMID: 11599040 Related articles

5. Transcription of homeobox-containing genes detected in cDNA libraries derived from human unfertilized oocytes and preimplantation embryos.

Adjaye J, Monk M.

Mol Hum Reprod. 2000 Aug;6(8):707-11.PMID: 10908280 Related articlesFree article

6. Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos.

Smelt VA, Upton A, Adjaye J, Payton MA, Boukouvala S, Johnson N, Mardon HJ, Sim E.

Hum Mol Genet. 2000 Apr 12;9(7):1101-7.PMID: 10767335 Related articlesFree article

7.Developmental expression of specific genes detected in high-quality cDNA libraries from single human preimplantation embryos.

Adjaye J, Bolton V, Monk M.

Gene. 1999 Sep 17;237(2):373-83.PMID: 10521661 Related articles

8. Identification of genes expressed in human primordial germ cells at the time of entry of the female germ line into meiosis.

Goto T, Adjaye J, Rodeck CH, Monk M.

Mol Hum Reprod. 1999 Sep;5(9):851-60.PMID: 10460224 Related articlesFree article

9.Detection of a novel splice variant of the hypoxanthine-guanine phosphoribosyl transferase gene in human oocytes and preimplantation embryos: implications for a RT-PCR-based preimplantation diagnosis of Lesch-Nyhan syndrome.

Daniels R, Adjaye J, Bolton V, Monk M.

Mol Hum Reprod. 1998 Aug;4(8):785-9.PMID: 9733436 Related articlesFree article

10. The construction of cDNA libraries from human single preimplantation embryos and their use in the study of gene expression during development.

Adjaye J, Daniels R, Monk M.

J Assist Reprod Genet. 1998 May;15(5):344-8.PMID: 9604772 Related articles

11. cDNA libraries from single human preimplantation embryos.

Adjaye J, Daniels R, Bolton V, Monk M.

Genomics. 1997 Dec 15;46(3):337-44.PMID: 9441736 Related articles

12.Characterisation of neurofilament protein NF70 mRNA from the gastropod Helix aspersa reveals that neuronal and non-neuronal intermediate filament proteins of cerebral ganglia arise from separate lamin-related genes.

Adjaye J, Plessmann U, Weber K, Dodemont H.

J Cell Sci. 1995 Nov;108 ( Pt 11):3581-90.PMID: 8586669 Related articlesFree article

13. Immunological properties and cDNA sequence analysis of an intermediate-filament-like protein from squid neuronal tissue.

Adjaye J, Marsh PJ, Eagles PA.

J Cell Sci. 1993 Dec;106 ( Pt 4):1283-90.PMID: 8126107 Related articlesFree article

last updated: 18 March, 2011