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(1)
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Transcriptional
and signal transduction mechanisms regulating self renewal and pluripotency
in human embryonic stem (hES) cells, embryonal carcinoma cells and iPS
cells (induced pluripotent stem cells).
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(2)
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Reprogramming of
somatic cells (healthy and diseased individuals- Alzheimer’s
Diabetic, Nijmegen
Breakage Syndrome and Steatosis patients) into an ES-like state (iPS cells)
and studying the underlying disease mechanisms.
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(3)
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Comparative characterisation of functional hepatocytes,
cardiomyocytes, pancreatic, and neuronal cells derived from human ES cells
and patient-specific iPS cells with the aim of establishing a platform for
toxicology studies and drug screens.
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(4)
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Systems biology of stem cell fate and cellular reprogramming.
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(5)
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Age-associated gene expression patterns and signal
transduction mechanisms employing mouse tissues, human bone marrow-derived
MSCs and fibroblast-derived iPS cells from young and aged individuals as
model systems.
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(6)
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Gene expression and signal transduction mechanisms
pertinent to preimplantation development
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