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Date	Comment	Related Article
May 14^th, 2012	Prof. James A. Adjaye zum W3- Professor ernannt Am 14. Mai 2012 erhielt Prof. Dr. James A. Adjaye seine Ernennungsurkunde zum W3-Professor für das Fach: „Stammzellforschung und Regenerative Medizin“. © Copyright 2010 Heinrich-Heine-Universität Düsseldorf See more Heinrich-Heine-Universität Düsseldorf
March 29^th,2012	James Adjaye is named Head of the Institute at Düsseldorf’s Heinrich-Heine University A new stem cell research institute is being formed which will make up a new part of the Institute for Transplantation Diagnostics and Cell Therapies (ITZ) at the Heinrich-Heine University in Düsseldorf, Germany:  Its head will be Dr. James Adjaye a Ghanaian born British citizen, who will be leaving the Max Planck Institute for Molecular Genetics in Berlin. His goal is the banking of clinical grade iPS cells (induced pluripotent stem cells) derived from cordblood cells with defined HLA haplotypes.  The latter has played an important role in immune compatibility for blood and organ donors, for example. Dr. Adjaye will succeed Prof. Peter Wernet, who was, until quite recently, the Director of the ITZ. Up until now, the primary tasks of the Institute have been the set up and development of stem cell transplantations from bone marrow and/or umbilical cord blood. Now this area will be extended to include research on iPS cells. “I start in May with a team of ten people”, says Dr. Adjaye. Up until now, his research interests have included, among other things, the development of human disease models in a cell culture dish, where he has concentrated mainly on a particular disease of the liver – referred to in vernacular as “Non-alcoholic fatty liver disease (NAFLD)” or steatosis. Cause of the disease is the increased prevalence of obesity, resulting in insulin resistance and excess fat accumulation in the liver, culminating in cirrhosis with liver failure and hepatocellular carcinoma. This disease is now acknowledged to be the most common liver problem in the Western world. © 2012 _Stem Cell Network North Rhine Westphalia See more the self-renewal of stem cells at a glance
March 22^th, 2012	The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts. This paper focuses on the major hurdles with induced pluripotent stem cell (iPS) technologies, which concern the delivery of the Yamanaka reprogramming factors. The risk of modifying the host genome by insertional mutagenesis makes iPS-derived cells not applicable for the generation of patient-specific transplantable cells. It is therefore of major importance to solve these problems in view of the availability of a potential therapeutic tool. Johann Bauer, Verena Wally and Eva Murauer, Paracelsus Private Medical University, Austria. F1000 Dermatology (Mar. 22, 2012) See more http://f1000.com	The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts. Drews K, Tavernier G, Demeester J, Lehrach H, De Smedt SC, Rejman J, Adjaye J. Biomaterials. 2012 Feb 28. [Epub ahead of print] PMID: 22381475
January 10^th, 2011	Induced Pluripotent Stem Cells from Fetal Skin Cells and Embryonic Stem Cells Display Comparable Potential for Derivation of Hepatocytes Numerous patients suffering from chronic liver diseases are currently receiving inadequate treatment due to the lack of organs donated for transplantation. However, hepatocytes derived from induced pluripotent stem cells (iPSCs) could offer an alternative for the future. Scientists from the Max Planck Institute for Molecular Genetics in Berlin compared hepatocytes from embryonic stem cells with hepatocytes from iPS cells and found that their gene expression is very similar. ScienceDaily (Jan. 10, 2011) See more www.sciencedaily.com	Comparative Analysis of Human Embryonic Stem Cell and Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells Reveals Current Drawbacks and Possible Strategies for Improved Differentiation. Jozefczuk J, Prigione A, Chavez L, Adjaye J. Stem Cells Dev. 2011 Jan 24. [Epub ahead of print] doi:10.1089/scd.2010.0361
November 19^th, 2010	Amniotic fluid cells have a number of advantages over other cell types. For one thing, amniotic fluid cells are routinely harvested in antenatal examinations to enable the early detection of disease. In most cases, more cells are obtained than are actually needed. In addition, the amniotic fluid mixture contains different types of cells from the unborn child, including stem-cell-like cells. As they are not very old, they have fewer environmentally-induced mutations, making them genetically more stable. News Staff; Scientific Blogging; Science 2.0 See more www.science20.com	The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells. Wolfrum K, Wang Y, Prigione A, Sperling K, Lehrach H, Adjaye J. PLoS One. 2010 Oct 29;5(10):e13703. doi:10.1371/journal.pone.0013703
April 20^th, 2010	Lowry B: „To my knowledge, this is the most complete description of mitochondrial function before and after reprogramming fibroblasts to a pluripotent state. As reprogramming to induced pluripotent stem cells (iPSCs) becomes commonplace, it is essential that mitochondrial function be accounted for.“ Faculty of 1000, 20 Apr 2010. F1000.com/2977956 See more F1000.com/2977956	The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells. Prigione A, Fauler B, Lurz R, Lehrach H, Adjaye J Stem Cells. 2010 Apr; 28(4):721-33 doi: 10.1002/stem.404
April 11^th, 2008	Leben unter Laborbedingungen Der Bundestag entscheidet heute über die hochumstrittene Stammzellforschung. Der Biochemiker James Adjaye betrachtet die Probleme durchs Mikroskop. [..] Die Menschen müssten besser Bescheid wissen, denkt er. Dann hätten sie nicht solche Vorbehalte. Gerne würde er sie alle mit embryonalem Anschauungsmaterial versorgen, im Glauben, dass das ihre ethischen Bedenken zerstreuen würde. Es ist nicht lange her, da kam ein junger Mann wütend in sein Labor. Berlin feierte die Lange Nacht der Wissenschaften, auch James Adjaye hatte seine Labortüren geöffnet. Aufgebracht blickte der Mann durchs Mikroskop auf Adjayes Stammzellen: "Wo sind sie denn nun, die Embryozellen?", fragte er ungehalten. Diese unscheinbaren Häufchen, das war alles? Den Besucher hätten erst recht die Embryonen enttäuscht, aus denen Adjayes Zellen stammen. Ein wenige Tage alter Embryo hat keine Augen, keine Arme, keine Beine. Er ist eine Kugel, gerade so groß wie der Punkt am Ende dieses Satzes. Christina Berndt; Sueddeutsche.de See more www.sueddeutsche.de
February 11^th, 2008	Rohstoff der Menschenwürde Der Bundestag debattiert, ob Embryonenforschung überflüssig ist, weil Zellen direkt verjüngt werden können. Kanzlerin Merkel mischt sich als oberste Naturwissenschaftlerin der Nation ein. James Adjaye wird am kommenden Donnerstag auf der Tribüne des Bundestags verfolgen, wie über seine Zukunft entschieden wird. Der Mann ist Stammzellforscher und gehört zu einer kleinen Gruppe von Wissenschaftlern, die nach Deutschland importierte Zellen aus menschlichen Embryonen untersuchen dürfen. Am Max-Planck-Institut für molekulare Genetik in Berlin-Dahlem fahndet Adjaye nach den Genen, die embryonale Stammzellen so besonders wandlungsfähig machen. Christian Schwägerl; DER SPIEGEL 7/2008 See more www.spiegel.de
January 17^th, 2008	Der Jungbrunnen Mit neuen Verfahren wachsen auch in Deutschland menschliche Stammzellen. Ist die Debatte um die Embryonenforschung überholt? Ulrich Bahnsen; DIE ZEIT, 17.01.2008 Nr. 04 See more www.zeit.de	A transcriptional roadmap to the induction of pluripotency in somatic cells. Wang Y, Mah N, Prigione A, Wolfrum K, Andrade-Navarro MA, Adjaye J. Stem Cell Rev. 2010 Jun;6(2):282-96. Review. doi: 10.1371/journal.pone.0013703.

last updated: 28 April 2011