Welcome to the Bioinformatics group homepage!

The Bioinformatics group of the department Lehrach has the following main areas of interest:

1.  Development of software and analysis tools for genomics and proteomics data, in particular for the analysis of data from DNA arrays, mass spectrometry, protein-protein and protein-DNA interactions. Methodologies focus on methods from multivariate statistics, for example testing statistical hypotheses, cluster analysis and classification and networks as well as functional annotation of sequence data.

2.  Methods for data integration, in particular for the storage, representation and linking of data from the above technologies. Methods comprise the development of common schemas, correlation analysis of heterogeneous data sources and databases.

3.  For systems biology applications the group has developed a modeling and simulation platform for the in silico analysis of complex biological processes, such as gene regulatory motifs, metabolic networks and signal transduction pathways. Specific efforts have been made for the integration of databases and experimental data into the kinetic models, for example in order to test mutations or to validate drug targets.