Max Planck Institute for Molecular Genetics

Max Planck Institute for Molecular Genetics - Ihnestraße 73 - 14195 Berlin - Germany - Phone: (+49 30) 8413 0 - Fax: (+49 30) 8413 1388

[home]

[contact]

[search]

[back to Vertebrate Genomics]

Biochemical Tools Group

 

Technologies

Team

Projects

Home

Funding

Links

Publications

Journal articles

31. Schlachter C, Lisdat F, Frohme M, Erdmann VE, Konthur Z, Lehrach H, Glökler J.
Pushing the detection limits: the evanescent field in surface plasmon resonance and analyte-induced folding observation of long human telomeric repeats.

Biosens Bioelectron. 2012 Jan 15;31(1):571-4. Epub 2011 Nov 10.
PMID: 22152989

30. Schütze T, Wilhelm B, Greiner N, Braun H, Peter F, Mörl M, Erdmann VA, Lehrach H, Konthur Z, Menger M, Arndt PF, Glökler J. (2011) PLoS ONE 6, e29604 Lisdat F, Frohme M, Erdmann VE, Konthur Z, Lehrach H, Glökler J.
Probing the SELEX process with next-generation sequencing.
PLoS One 2011 Dec;6(12):e29604. Epub 2011 Dec 29.
PMID: 22242135

29. Lim TS, Schütze T, Lehrach H, Glökler J, Konthur Z.
Diversity Visualization by Endonuclease – A rapid assay to monitor diverse nucleotide libraries.
Anal Biochem. 2011 Apr;411(1):16-21. Epub 2010 Dec 22.
PMID: 21185254
Evaluated and rated on Faculty of 1000 Biology

28. Schütze T, Rubelt F, Repkow J, Greiner N, Erdmann VA, Lehrach H, Konthur Z, Glökler J.
A streamlined protocol for emulsion PCR and subsequent purification.
Anal Biochem. 2011 Mar;410(1):155-7. Epub 2010 Nov 24.
PMID: 21111698

27. Georgieva Y, Konthur Z.
Design and Screening of M13 Phage Display cDNA Libraries.
Molecules. 2011 Feb;16(2):1167-81.
PMID: 21330956

26. Hallen L, Klein H, Stoschek C, Wehrmeyer S, Nonhoff U, Ralser M, Wilde J, Röhr C, Schweiger MR, Zatloukal K, Vingron M, Lehrach H, Konthur Z, Krobitsch S.
The KRAB-containing zinc-finger transcriptional regulator ZBRK1 activates SCA2 gene transcription through direct interaction with its gene product, ataxin-2.
Hum Mol Genet. 2011 Jan;20(1):104-14. Epub 2010 Oct 6.
PMID: 20926453

25. Bourbeillon J, Orchard S, Benhar I, Borrebaeck C, de Daruvar A, Dübel S, Frank R, Gibson F, Gloriam D, Haslam N, Hiltke T, Humphrey-Smith I, Hust M, Juncker D., Koegl M, Konthur Z, Korn B, Krobitsch S, Myldermans S, Nygren PA, Palcy S, Polic B, Rodriguez H, Sawyer A, Schlapschy M, Snyder M, Stoevesandt O, Taussig MJ, Templin M, Uhlen M, van der Maarel S, Wingren C, Hermjakob H, Sherman D.
Minimum information about a protein affinity reagent (MIAPAR).
Nat Biotechnol. 2010 Jul;28(7):650-3.
PMID: 20622827

24. Lim TS, Mollova S, Rubelt F, Sievert V, Dübel S, Lehrach H, Konthur Z.
V–gene amplification revisited – An optimised procedure for amplification of rearranged human antibody genes of different isotypes.
N Biotechnol. 2010 May;27(2):108-17. Epub 2010 Jan 18.
PMID: 20083243

23. Glökler J, Schütze T, Konthur Z.
Automation in the High-throughput Selection of Random Combinatorial Libraries––Different Approaches for Select Applications.
Molecules. 2010 Apr;15(4):2478-90.
PMID: 20428057

22. Galiveti CR, Rozhdestvensky TS, Brosius J, Lehrach H, Konthur Z.
Application of housekeeping npcRNAs for quantitative expression analysis of human transcriptome by real-time PCR.
RNA. 2010 Feb;16(2):450-61. Epub 2009 Dec 29.
PMID: 20040593

21. Gloriam DE, Orchard S, Bertinetti D, Björling E, Bongcam-Rudloff E, Bourbeillon J, Bradbury AR, de Daruvar A, Dübel S, Frank R, Gibson TJ, Gold L, Haslam N, Herberg FW, Hiltke T, Hoheisel JD, Kerrien S, Koegel M, Konthur Z, Korn B, Landegren U, van der Maarel S, Montecchi-Palazzi L, Palcy S, Rodriguez H, Schweinsberg S, Sievert V, Stoevesandt O, Taussig MJ, Uhlen M, Wingren C, Woollard P, Sherman DJ, Hermjakob H.
A community standard format for the representation of protein affinity reagents.
Mol Cell Proteomics. 2010 Jan;9(1):1-10. Epub 2009 Aug 11.
PMID: 19674966

20. Menzel C, Schirrmann T, Konthur Z, Jostock T, Dübel S.
Human antibody RNase fusion protein targeting CD30+ lymphomas.
Blood. 2008 Apr;111(7):3830-7. Epub 2008 Jan 29.
PMID: 18230757

19. Taussig MJ, Stoevesandt O, Borrebaeck CA, Bradbury AR, Cahill D, Cambillau C, de Daruvar A, Dübel S, Eichler J, Frank R, Gibson TJ, Gloriam D, Gold L, Herberg FW, Hermjakob H, Hoheisel JD, Joos TO, Kallioniemi O, Koegl M, Konthur Z, Korn B, Kremmer E, Krobitsch S, Landegren U, van der Maarel S, McCafferty J, Muyldermans S, Nygren PA, Palcy S, Plückthun A, Polic B, Przybylski M, Saviranta P, Sawyer A, Sherman DJ, Skerra A, Templin M, Ueffing M, Uhlen M.
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome.
Nat Methods. 2007 Jan;4(1):13-7.
PMID: 17195019

18. Angenendt P, Kreutzberger J, Glökler J, Hoheisel JD.
Generation of high-density protein micorarrays by cell-free in situ expression of unpurified PCR products.
Mol Cell Proteomics. 2006 Sep;5(9):1658-66. Epub 2006 Jul 5.
PMID: 16376134

17. Hultschig C, Kreutzberger J, Seitz H, Konthur Z, Büssow K, Lehrach H.
Recent advances of protein microarrays.
Curr Opin Chem Biol. 2006 Feb;10(1):4-10. Epub 2005 Dec 22.
PMID: 16376134

16. Sauer S, Konthur Z, Lehrach H.
Genome projects and the functional-genomic era.
Comb Chem High Throughput Screen. 2005 Dec;8(8):659-67.
PMID: 16464154

15. Konthur Z, Hust M, Dübel S.
Perspectives for systematic in vitro antibody generation.
Gene. 2005 Dec;364:19-29. Epub 2005 Aug 26. PMID: 16126351

14. Angenendt P, Wilde J, Kijanka G, Baars S, Cahill DJ, Kreutzberger J, Lehrach H, Konthur Z, Glökler J.
Seeing better through a MIST: evaluation of monoclonal recombinant antibody fragments on microarrays.

Anal Chem. 2004 May;76(10):2916-21.
PMID: 15144205

13. Krenn V, Petersen I, Haupl T, Koepenik A, Blind C, Dietel M, Konthur Z, Skriner K.
Array technology and proteomics in autoimmune diseases.
Pathol Res Pract. 2004;200(2):95-103.
PMID: 15237918

12. Konthur Z and Crameri R.
High-throughput applications of phage display in proteomic analyses.
TARGETS. 2003 Dec;2(6):261-70.
ScienceDirect

11. Rhyner C, Konthur Z, Blaser K, Crameri R.
High-throughput isolation of recombinant antibodies against recombinant allergens.
Biotechniques. 2003 Oct;35(4):672-4.
PMID: 14579728

10. Angenendt P, Glökler J, Konthur Z, Lehrach H, Cahill DJ.
3D protein microarrays: performing multiplex immunoassays on a single chip.
Anal Chem. 2003 Sep;75(17):4368-72.
PMID: 14632038

9. Kodzius R, Rhyner C, Konthur Z, Buczek D, Lehrach H, Walter G, Crameri R.
Rapid identification of allergen-encoding cDNA clones by phage display and high-density arrays.
Comb Chem High Throughput Screen. 2003 Mar;6(2):147-54.
PMID: 12678710

8. Kersten B, Bürkle L, Kuhn EJ, Giavalisco P, Konthur Z, Lueking A, Walter G, Eickhoff H, Schneider U.
Large-scale plant proteomics.
Plant Mol Biol. 2002 Jan;48(1-2):133-41.
PMID: 11860206

7. Konthur Z and Walter G.
Automation of phage display for high-throughput antibody development.
TARGETS. 2002 Jul;1(1):30-36.
ScienceDirect

6. Eickhoff H, Konthur Z, Lueking A, Lehrach H, Walter G, Nordhoff E, Nyarsik L, Büssow K.
Protein array technology: the tool to bridge genomics and proteomics.
Adv Biochem Eng Biotechnol. 2002;77:103-12.
PMID: 12227733

5. Crameri R, Kodzius R, Konthur Z, Lehrach H, Blaser K, Walter G.
Tapping allergen repertoires by advanced cloning technologies.
Int Arch Allergy Immunol. 2001 Jan-Mar;124(1-3):43-7.
PMID: 11306922

4. Walter G, Konthur Z, Lehrach H.
High-throughput screening of surface displayed gene products.
Comb Chem High Throughput Screen. 2001 Apr;4(2):193-205.
PMID: 11281835

3. Lueking A, Konthur Z, Eickhoff H, Büssow K, Lehrach H, Cahill, DJ.
Protein Microarrays - A Tool for the Post-Genomic Era.
Curr Genomics. 2001 Jun;2(2):151-9.
Bentham Science Publishers

2. Büssow K, Konthur Z, Lueking A, Lehrach H, Walter G.
Protein array technology. Potential use in medical diagnostics.
Am J Pharmacogenomics. 2001;1(1):37-43.
PMID: 12173313

1. Giege P, Konthur Z, Walter G, Brennicke A.
An ordered Arabidopsis thaliana mitochondrial cDNA library on high-density filters allows rapid systematic analysis of plant gene expression: a pilot study.
Plant J. 1998 Sep;15(5):721-6.
PMID: 9778852

 

Book chapters

8. Chin ST, Choong YS, Konthur Z, Lim TS.
Generation of recombinant antibodies by display technologies (2011)
In Sustainable Diagnostics for the Bottom Millions, Oxford Academic Press (A. Acosta, N.M. Nor & M.E. Sarmiento, Eds.), in press.

7. Konthur Z, Wilde J, Lim TS.
Chapter 18: Semi-automated Magnetic Bead-Based Antibody Selection from Phage Display Libraries (2010)
In
Antibody Engineering Vol. 1, 2nd Edition, Springer-Verlag (R. Kontermann & S. Dübel, Eds.), ISBN: 978-3-642-01143-6, pages 265-285.

6. Konthur Z, Wilde J.
Chapter 34: Evaluation of Recombinant Antibodies on Protein Microarrays Applying the Multiple Spotting Technique (2010)
In
Antibody Engineering Vol. 2, 2nd Edition, Springer-Verlag (R. Kontermann & S. Dübel, Eds.), ISBN: 978-3-642-01143-7, pages 447-460.

5. Walter G, Büssow K, Konthur Z, Lueking A, Glökler J, Schneider U.
Array-based proteomics (2008)
In
Handbook of Proteins: Structure, Function and Methods John Wiley & Sons (M.M. Cox & G.N. Phillips, Jr Eds.), ISBN: 978-0-470-06098-8, pages 1133-1237.

4. Konthur Z.
Automation of Selection and Engineering (2007)
In
Handbook of Therapeutic Antibodies Wiley-VCH (S. Dübel, Ed.), ISBN: 978-3-527-31453-9, pages 413-430.

3. Konthur Z, Glökler J, Skriner K.
Protein Interaction Analysis: Phage Display (2006)
In
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine Springer-Verlag (D. Ganten & K. Ruckpaul, Eds.), ISBN: 978-3-540-44244-8, pages 1509-1514.

2. Crameri R, Rhyner C, Flückinger S, Konthur Z, Weichel M.
Identification of natural protein-protein interactions with cDNA libraries (2005)
In
Phage Display in Biotechnology and Drug Discovery CRC Press, Taylor & Francis Group (S.S. Sidhu, Ed.), ISBN: 978-0-824-75466-2, pages 415-440.

1. Walter G, Büssow K, Konthur Z, Lueking A, Glökler J, Schneider U.
Array-based proteomics (2003)
In
Encyclopedia of the Human Genome John Wiley & Sons (D.N. Cooper, Ed.), ISBN: 978-0-470-01618-3, pages 182-87.

 

Published meeting abstracts

20. Konthur Z, Köpke K, Lehrach H, Burmester GR, Skriner K.
Protein Array Screening Reveals Autoantigenicity Patterns Predicting Anti-TNF Alpha Therapy Response in Rheumatoid Arthritis Patients.
Arthritis & Rheumatism 2011 Oct;63(10;Supplement):S331.

19. Marklein B, Konthur Z, Burmester G, Skriner K.
Anti-hnRNP Autoantibodies Detected in Inflammatory Rheumatic Diseases in Use to Close the Sensitivity gap left by Rheumatoid Factor and Anti-CCP in Early Rheumatoid Arthritis.
Arthritis & Rheumatism 2011 Oct;63(10;Supplement):S686.

18. Konthur Z, Kopke K, Poch-Hasnek A, Lehrach H, Burmester GR, Skriner K.
Protein array screening reveals IgA autoantigenicity patterns predicting anti-TNFα therapy response in rheumatoid arthritis patients.
Ann Rheum Dis. 2011;70:A69-A70. doi:10.1136/ard.2010.149013.5

17. Marklein B, Konthur Z, Häupl T, Shlomchik MJ, Steiner G, Lehrach H, Burmester GR, Apparailly F, Skriner K.
Toll-like receptor dependent autoantigens in animal models and humans in unse to improve collagen induced arthritis.
J Transl Med. 2010 Nov; 8(Suppl 1):P53. doi:10.1186/1479-5876-8-S1-P53

16. Marklein B, Konthur Z, Häupl T, Shlomchik M, Burmester G, Skriner K.
Toll-like receptor (TLR-7/9), MYOD88, TIR8, dependent and independent autoantigens.
Int Immunol. 2010 Aug; 22(Suppl 1 Pt 1): i8. doi:10.1093/intimm/dxq155

15. Rubelt F, Lim TS, Sievert V, Lehrach H, Skriner K, Konthur Z.
Analysis of human antibody repertoires in health and disease by next generation sequencing.
Int Immunol. 2010 Aug; 22(Suppl 1 Pt 4): iv91. doi:10.1093/intimm/dxq260

14. Marklein B, Konthur Z, Cope A, Shlomchik M, Burmester G, Skriner K.
JKTBP (HNRNPDL) is a novel toll7/9 dependent target in humans and animal models of inflammatory rheumatic diseases.
Ann Rheum Dis. 2010 Mar;69:A4. doi:10.1136/ard.2010.129577h

13. Marklein B, Konthur Z, Häupl T, Cope A, Shlomchik M, Steiner G, Burmester G, Skriner K.
Toll-like receptor (TLR-7/9), MYOD88, TIR8, dependent and independent autoantigens.
Ann Rheum Dis. 2010 Mar;69:39. doi: 10.1136/ard.2010.129627j

12. Wuderlich A, Krobitsch S, Konthur Z, Lange B, Glökler J, Hussong M, Howley P, Lehrach H, Schweiger MR.
The genome maintenance and transcriptional regulation mechanisms of human high risk papillomaviruses as target points for antiviral treatment and cervical cancer prevention.
Onkologie. 2010 Feb; 33(Suppl. 2):115

11. Skriner K, Konthur Z, Häupl T, Märklein B, Christensen SR, Shlomchik MJ, Cope A, Steiner G, Lehrach H, Burmester GR.
Comparative immunomics in human and animal models of inflammatory rheumatic diseases reveals toll-like receptor (7/9) dependent and independent autoantigens.
Ann Rheum Dis. 2009 Mar; 68:A36

10. Skriner K, Konthur Z,Häupl T, Burmester GR.
Transglutaminated and citrullinated proteins are targeted by rheumatoid arthritis patient sera
Ann Rheum Dis. 2008 Mar;67:A3.

9. Skriner K, Konthur Z, Förster A, Burmester GR
C-reactive protein (CRP), serum amyloid P component (SAP) bind to hnRNPs and other RNA or DNA binding autoantigens: Indetification of a short polypeptide binding region.
Ann Rheum Dis. 2008 Mar;67:A7.

8. Skriner K, Konthur Z, Hollidt J, Adolph K, Burmester G.
A significant proportion of RA patients exhibit autoantibodies to the celiac antigen tissue transglutaminase and gliadin as well as to CCP - Possible inducing by transgilutamidation of synovial proteins.
Ann Rheum Dis. 2006 Jul;65(Suppl 2):103

7. Skriner K, Konthur Z, Häupl T, Adolph K, Burguera G, Sternjak A, Förster A, Lehrach H, Hollidt J, Burmerster G.
A novel immunomic approach combining proteomic fingerprinting and gene expression analysis leads to the identification of new autoantigens in rheumatoid arthritis.
Ann Rheum Dis. 2006;65(Suppl 2):301

6. Skriner K, Konthur Z, Häupl T, Adolph K, Burguera G, Sternjak A, Förster A, Lehrach H, Burmester GR.
Immunomics in inflammatory rheumatic diseases.
Ann Rheum Dis. 2006 Apr;65(Suppl 1):A5

5. Skriner K, Konthur Z, Adolph K, Burmester GR.
Tissue transglutaminase in rheumatoid arthritis.
Ann Rheum Dis. 2006 Apr;65(Suppl 1):A17

4. Konthur Z, Wilde J, Langner J, Stoschek C, Lehrach H, Kreutzberger J.
The Use of Protein Microarrays for the Validation of Phage Display Antibody Selections within the German NGFN Initiative Antibody Factory.
Mol Cell Proteomics. 2005 Aug;4(8):S332

3. Kreutzberger J, Steller S, Cahill D, Lehrach H, Konthur Z
Combined Protein/Antibody Microarrays for Investigation of Bacterial Meningitis.
Mol Cell Proteomics. 2005 Aug;4(8):S333

2. Konthur Z, Adolph K, Burguera H, Sternjak A, Förster A, Lehrach H, Burmester GR, Skriner, K.
Immunomics in inflammatory rheumatic diseases.
Arthritis Res Ther 2004;6(Suppl 1):13

1. Skriner K, Sternjak A, Wilde J, Adolph K, Adjaye J, Hultschig C, Herwig R, Burmester GR, Lehrach H, Konthur Z.
Isolation of novel autoantigens in rheumatoid arthritis by a combination of phage display and DNA array technology.

Tissue Antigens 2004;64(4):410

 

Public relations

4. Georgieva Y.
Qual der Wahl für Absolventen.
transkript 2010; 16(3): 61.

3. Konthur Z.
Q&A: Researchers Propose 'Housekeeping RNAs' for Real-Time PCR Studies of Noncoding RNAs.
Genomeweb – PCR Insider 2010; January 14.

2. Konthur Z.
Interview for: A Planck Walk.
The Scientist 2008; 22(7):46-53.

1. Schirrmann T, Hust M, Konthur Z, Frank R, Toleikis L, Dübel S.
Schlüsselreagenzien für die Proteomforschung im Hochdurchsatz.
Laborwelt 2/2007:16-20.

 

Disclaimer: Download of PDF files is only allowed for personal use.

 

 

 

last updated: 2 January, 2012