Sperling Lab - Max Planck Institute for Molecular Genetics

Publications

2012

2011

Book Chapters and Reviews

Public Science

Meeting Reports

2012

Dynamics of Srf, p300 and histone modifications during cardiac maturation in mouse
Schueler M*, Zhang Q*, Schlesinger J, Tönjes M and Sperling SR (*shared authorship)
Mol. BioSyst., 8 (2), 495 - 503

2011

Ebstein's anomaly may be caused by mutations in the sarcomere protein gene MYH7
van Engelen K, Postma AV, van de Meerakker JB, Roos-Hesselink JW, Helderman-van den Enden AT, Vliegen HW, Rahman T, Baars MJ, Sels JW, Bauer U, Pickardt T, Sperling SR, Moorman AF, Keavney B, Goodship J, Klaassen S, Mulder BJ
Netherlands Heart Journal. doi: 10.1007/s12471-011-0141-1

Systems biology approaches to heart development and congenital heart disease
Sperling S
Cardiovascular Research 2011; doi: 10.1093/cvr/cvr126

The Cardiac Transcription Network Modulated by Gata4, Mef2a, Nkx2.5, Srf, Histone Modifications, and MicroRNAs
Schlesinger J*, Schueler M*, Grunert M*, Fischer JJ*, Zhang Q, Krueger T, Lange M, Tönjes M, Dunkel I, and Sperling SR (*shared authorship)
PLoS Genet 7(2): e1001313. doi:10.1371/journal.pgen.1001313

2010

The Effect of Micrococcal Nuclease Digestion on Nucleosome Positioning Data
Chung HR, Dunkel I, Heise F, Linke C, Krobitsch S, Ehrenhofer-Murray AE, Sperling SR, and Vingron M
PLoS ONE 5(12): e15754. doi:10.1371/journal.pone.0015754

Identification of Y-Box Binding Protein 1 As a Core Regulator of MEK/ERK Pathway-Dependent Gene Signatures in Colorectal Cancer Cells
Jürchott K, Kuban RJ, Krech T, Blüthgen N, Stein U, Walther W, Friese C, Kielbasa SM, Ungethüm U, Lund P, Knösel T, Kemmner W, Morkel M, Fritzmann J, Schlag PM, Birchmeier W, Krueger T, Sperling SR, Sers C, Royer HD, Herzel H, and Schäfer R
PLoS Genet 6(12): e1001231. doi:10.1371/journal.pgen.1001231

Mutations in the Sarcomere Protein Gene MYH7 in Ebstein's Anomaly
Postma AV, van Engelen K, van de Meerakker J, Rahman T, Probst S, Baars MJ, Bauer U, Pickardt T, Sperling SR, Berger F, Moorman AF, Mulder BJ, Thierfelder L, Keavney B, Goodship J, Klaassen S.
Circ Cardiovasc Genet, 2010 Dec 2. doi:10.1161/CIRCGENETICS.110.957985

Evaluation of the LightCycler© 1536 Instrument for high-throughput quantitative real-time PCR
Schlesinger J, Tönjes M, Schueler M, Zhang Q, Dunkel I, and Sperling SR
Methods 2010 Apr;50(4):S19-S22

2009

MicroRazerS: Rapid alignment of small RNA reads
Emde AK*, Grunert M*, Weese D, Reinert K, and Sperling SR (*shared authorship)
Bioinformatics 2009

2008

Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex
Lange M, Kaynak B, Forster UB, Toenjes M, Fischer JJ, Grimm C, Schlesinger J, Just S, Dunkel I, Krueger T, Mebus S, Lehrach H, Lurz R, Gobom J, Rottbauer W, Abdelilah-Seyfried S, and Sperling S
Genes & Development 22(17):2370-84 2008. see supplement see movies 1, 2

Molecular BioSystems Emerging Investigators theme issue

Prediction of cardiac transcription networks based on molecular data and complex clinical phenotypes
Toenjes M*, Schueler M*, Hammer S, Pape UJ, Fischer JJ, Berger F, Vingron M, and Sperling S. (*shared authorship)
Molecular BioSystems 4:589-598 2008. see supplement

Characterization of TBX20 in human hearts and its regulation by TFAP2
Hammer S*, Toenjes M*, Lange M, Fischer JJ, Dunkel I, Mebus S, Grimm CH, Hetzer R, Berger F, and Sperling S. (*shared authorship)
Journal of Cellular Biochemistry 104(3):1022-33 2008.

Combinatorial effects of four histone modifications in transcription and differentiation
Fischer JJ, Toedling J, Krueger T, Schueler M, Huber W, and Sperling S.
Genomics 91/1: 41-51 2008 see supplement

2007

BMPR IA Downstream Genes Related to VSD
Yang D, Zhang J, Chen C, Xie M, Sperling S, Fang F, Chen B, Li X, and Zhang H.
Pediatric Research 63(6):602-606 2008

Ringo - an R/Bioconductor package for analyzing ChIP-chip readouts
Toedling J, Skylar O, Krueger T, Fischer JJ, Sperling S, and Huber W.
BMC Bioinformatics 8(1):443. 2007.

Genomic organization of transcriptomes in mammals: Co-regulation and co-functionality
Purmann A, Toedling J, Schueler M, Carninci P, Lehrach H, Hayashizaki Y, Huber W, and Sperling S.
Genomics 89: 580-587. 2007. see supplement

2006

A new statistical model to select target sequences bound by transcription factors.
Pape UJ, Grossmann S, Hammer S, Sperling S, and Vingron M
Genome Informatics 17: 134-140. 2006.

TaqMan probe array for quantitative detection of DNA targets
Heping L, Hong W, Zhiyang S, Hua W, Chaoyong Y, Sperling S, Weihong T, and Zuhong L.
Nucleic Acids Research 2006, 34:1.

2005

A physiogenomic approach to study the regulation of blood pressure.
Westhoff TH, Scheid S, Tolle M, Kaynak B, Schmidt S, Zidek W, Sperling S*, and van der Giet M.* (*shared authorship)
Physiological Genomics 2005.

Chromosomal clustering of a human transcriptome reveals regulatory background.
Vogel J, von Heydebreck A, Purmann A, and Sperling S.
BMC Bioinformatics 2005, 6:230. see supplement 1, 2, 3

Identification and functional analysis of CITED2 mutations in patients with congenital heart defects.
Sperling S, Grimm C, Dunkel I, Mebus S, Sperling H, Ebner A, Galli R, Lehrach H, Fusch C, Berger F, and Hammer S.
Human Mutation 2005 Dec;26(6):575-82. see web supplement

The transcriptional landscape of the mammalian genome.
Carninci PT, Kasukawa S, Katayama J, Gough MC, Frith N, Maeda R, Oyama T, Ravasi B, Lenhard C, Wells R et al.
Science 2005;309:1559-63. see supplement

2004

Genexpressionsanalyse komplexer klinischer Phenotypen mittels cDNS-Arrays - Gene Expression Profiling of Complex Clinical Phenotypes using cDNA-Arrays.
von Heydebreck A, Sperling S, Kaynak B, Lehrach H, and Vingron M.
it - Information Technology 2004:26-30.

d-matrix - database exploration, visualisation and analysis.
Seelow D, Galli R, Mebus S, Sperling HP, Lehrach H, and Sperling S.
BMC Bioinformatics 2004;5:168. see web supplement

Multiplexed real-time PCR using universal reporters.
Rickert AM, Lehrach H, and Sperling S.
Clinical Chemistry 2004;50:1680-3.

Refinement of single-nucleotide polymorphism genotyping methods on human genomic DNA: amplifluor allele-specific polymerase chain reaction versus ligation detection reaction-TaqMan.
Rickert AM, Borodina TA, Kuhn EJ, Lehrach H, and Sperling S.
Analytical Biochemistry 2004;330:288-97.

2003

Genome-wide array analysis of normal and malformed human hearts.
Kaynak B, von Heydebreck A, Mebus S, Seelow D, Hennig S, Vogel J, Sperling HP, Pregla R, Alexi-Meskishvili V, Hetzer R, Lange PE, Vingron M, Lehrach H, and Sperling S.
Circulation 2003;107:2467-74. see web supplement

2001

Triple A syndrome is caused by mutations in AAAS, a new WD-repeat protein gene.
Handschug K, Sperling S, Yoon SJ, Hennig S, Clark AJ, and Huebner A.
Human Molecular Genetics 2001;10:283-90.

Book Chapters and Reviews

Transcriptional regulation at a glance.
Sperling S.
BMC Bioinformatics 2007; 8(Suppl 6):S2.

Array analysis applied to maformed hearts: Molecular Dissection of Tetralogy of Fallot.
Sperling S.
In: Kearns M., ed. Congenital Heart Disease: Molecular Diagnostics: pp 233-246. Humana Press; 2006.

Microarrays for the transcriptional regulation process.
Hammer, S. and S. Sperling.
In: Nongyue H., ed. Biochips Nanotechnology: p 1-18 American Scientific Publishers; 2009.

Public Science

Komplex und flexibel - die Regulation der kardialen Genexpression
Schlesinger J, Schueler M, and Sperling S.
Laborwelt, 02.11, S. 10-12.

Hochdurchsatz-Expressionsanalyse kardialer Gene.
Tönjes M, Schlesinger J, Schueler M, Dunkel I, Bethune J, and Sperling S.
Biospektrum, 02.10, S. 200-201.

High-Throughput Cardiac Gene Expression Analysis Using the Universal ProbeLibrary and the Novel LightCycler® 1536 Real-Time PCR System.
Tönjes M, Schlesinger J, Schueler M, Dunkel I, Bethune J, and Sperling S.
Biochemica, 1/2010, S. 2-4.