The systematic analysis
of human interindividual genetic variation
in relation to disease, gene function and individually different drug
response
has been the longstanding focus of our research.
Our
research topics are:
The
systematic analysis of genetic variation in all functionally important
regions
of candidate genes by application of high throughput comparative
sequencing and
genotyping technologies
The
analysis of the amount, nature, and organization of genetic variation
(SNPs) in
genes and genomic regions of interest
The
systematic analysis of haplotype structures by application of molecular
genetic
and in silico techniques
The
analysis of complex haplotype/genotype phenotype relationships and the
identification of genetic risk profiles and diagnostic markers
The
development of in vitro and in silico approaches and
technologies
to the (molecular) genetic and functional analysis of gene-based
haplotype
structures, multiple individually different gene profiles given
Contributions
to the ‘International HapMap Project’
through the analysis of high
resolution
genetic variation data and resulting haplotype (block) structures in
comparison
to HapMap-based haplotype structures
