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- Poustka AJ, Groth D, Hennig S, Thamm S, Cameron A, Beck A, Reinhardt R, Herwig R, Panopoulou G, Lehrach H: Generation, annotation, evolutionary analysis, and database integration of 20,000 unique sea urchin EST clusters. Genome Res 2003, 13:2736-2746, PMID: 14656975
- Poustka AJ, Herwig R, Krause A, Hennig S, Meier-Ewert S, Lehrach H: Toward the gene catalogue of sea urchin development: the construction and analysis of an unfertilized egg cDNA library highly normalized by oligonucleotide fingerprinting. Genomics 1999, 59:122-133, PMID: 10409423
- Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, et al.: The genome of the sea urchin Strongylocentrotus purpuratus. Science 2006, 314:941-952, PMID: 17095691
Relevant Group Publications: Genomics 1999, Genome Res 2003, Science 2006.
We have analyzed a total of 107,283 cDNA clones of libraries that span the development of the sea urchin Strongylocentrotus purpuratus. Normalization by oligonucleotide fingerprinting, EST sequencing and sequence clustering resulted in an EST catalog comprised of 20,000 unique genes or gene fragments [1,2]. This unigene set has helped in the annotation of the seaurchin genome [3].
We have setup a comprehensive database that allows the retrieval of any infomation stemming from various EST, genome projects and microarray screens in the californian purple sea urchin Strongylocentrotus purpuratus. In the future this database will incorporate the data generated by the large scale genomic project for the european sea urchin Paracentrotus lividus that has just started.
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