Matrix CGH

A high-resolution matrix CGH method utilizing DNA chips consisting of arrayed genomic DNA fragments is being used and will be further refined to screen large patient populations for microdeletions/duplications. Differentially labeled patient and reference DNA is cohybridized on DNA microarrays to identify fluorescent signal differences due to loss or excess of genomic sequences.

This project is done in collaboration with the molecular cytogenetics and chromosome evolution group and the neurogenetics group.