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Evolutionary Genomics Group Department of Computational Molecular Biology |
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Title: Solvable sequence evolution models and genomic correlations. Authors: Philipp W Messer, Peter F Arndt, Michael Lässig Abstract: We study a minimal model for genome evolution whose elementary processes are single site mutation, duplication and deletion of sequence regions, and insertion of random segments. These processes are found to generate long-range correlations in the composition of letters as long as the sequence length is growing; i.e., the combined rates of duplications and insertions are higher than the deletion rate. For constant sequence length, on the other hand, all initial correlations decay exponentially. These results are obtained analytically and by simulations. They are compared with the long-range correlations observed in genomic DNA, and the implications for genome evolution are discussed. Reference: Physical Review Letters 94 (2005) 138103 Links: [Fulltext (pdf)] |