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Evolutionary Genomics Group Department of Computational Molecular Biology |
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Title: Regional and time-resolved mutation patterns of the human genome. Authors: Peter F Arndt, Terence Hwa Abstract: MOTIVATION:Substantial regional variations of substitutional processes have recently been reported from human/mouse comparisons. However, several features including the C + G dependence and the CpG-based transition effect remain obscure. RESULTS:Utilizing the vast amount of transposable elements in the human genome, we performed detailed analysis of the substitutional and insertion/deletion patterns along the human lineage in a regional and time-resolved fashion. We observed a drastic increase in the CpG-based transition frequency at about the time of the mammalian radiation. We also observed clear regional biases of substitution patterns, most notably a bias to enrich the C+G content toward the telomeres. AVAILABILITY:The programs used are available upon request from the authors. Reference: Bioinformatics (Oxford, England) 20 (2004) 1482-1485 Links: [Journal] [Fulltext (pdf)] |