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Evolutionary Genomics Group Department of Computational Molecular Biology |
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Title: The History of Nucleotide Substitution Pattern in Human Authors: Peter F Arndt Abstract: Substantial regional variations of substitutional processes have recently been reported from human/mouse comparisons. However, several features including the C + G dependence and the CpG-based transition effect remain obscure. Utilizing the vast amount of transposable elements in the human genome, we performed detailed analysis of the substitutional and insertion/deletion patterns along the human lineage in a regional and time-resolved fashion. We observed a drastic increase in the CpG-based transition frequency at about the time of the mammalian radiation. We also observed clear regional biases of substitution patterns, most notably a bias to enrich the C+G content toward the telomeres. Reference: Biophysics 48 (2003) 585-589 Links: [Fulltext (pdf)] |