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Research Projects Overview:
1. X-ray crystallography of ribosomes
Antibiotic interaction with the small and large subunit
Ribosome recycling factor interaction with the large subunit
The Ribosome modulation factor (RMF) binds the active center of the large subunit
The trigger factor chaperone binds at the tunnel exit site of the large subunit unit
2. Cryo-electron microscopy on ribosome-functional complexes
Studying the stalled nascent chain complexes
Ribosomal subunit assembly factor complexes
Ribosome functional complexes
3. NMR to study the dynamic of ribosomes
Dynamics of the pentameric stalk complex on the E. coli ribosome
4. Dissecting ribosome composition and stability using Mass spectrometry
Ribosome Stability
Plant Ribosome composition
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