Publications

2012

Felix Dreher, Thomas Kreitler, Christopher Hardt, Atanas Kamburov, Reha Yildirimman, Karl Schellander, Hans Lehrach, Bodo M.H. Lange and Ralf Herwig.
DIPSBC - Data Integration Platform for Systems Biology Collaborations
BMC Bioinformatics 2012, 13:85 [Epub ahead of print], (2012).

A. Haupt, G. Joberty, M. Bantscheff, H. Fröhlich, H. Stehr, M. R. Schweiger, A. Fischer, M. Kerick, S.T. Boerno, A. Dahl, M. Lappe, H. Lehrach, C. Gonzalez, G. Drewes and B.M.H. Lange.
Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics.
BMC Cancer, Jan 25;12(1):38. [Epub ahead of print], (2012).

2011

Lange, B.M.H.; Schweiger, R.M.; Lehrach, H.
Global molecular and cellular measurement technologies. book chapter in: Cesario A and Marcus F B (editors) Springer Dordrecht Heidelberg London New York,
Cancer Systems Biology: Bioinformatics and Medicine: Research and Clinical Applications, (2011).

Henning Stehr, Seon-Hi J Jang, José M Duarte, Christoph Wierling, Hans Lehrach, Michael Lappe and Bodo MH Lange.
The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors.
Molecular Cancer, May 16;10:54. (2011).

Becla, L., Lunshof, J.E., Gurwitz, D., Schulte In den Bäumen, T., Westerhoff, H.V., Lange, B.M.H., Brand, A.
Health technology assessment in the era of personalized health care.
Int J Technol Assess Health Care, 30:1-9 (2011).

Müller, H., Schmidt, D., Dreher, F., Herwig, R., Ploubidou, A., Lange, B.M.H.
Gene ontology analysis of the centrosome proteomes of Drosophila and human.
Addendum for Communicative & Integrative Biology 4(3): 308-311 (2011).

2010

Lange, B.M.H.
Protein complexes and their function in cell division pathways in health and disease.
Cell News 36:28-31 (2010)

Müller, H., Schmidt, D., Steinbrink, S., Mirgorodskaya, E., Lehmann, V., Habermann, K., Dreher, F., Gustavsson, N., Kessler, T., Lehrach, H., Herwig, R., Gobom, J., Ploubidou, A., Boutros, M., Lange, B.M.H.
Proteomic and functional analysis of the mitotic Drosophila centrosome.
EMBO Journal, 29:3344-3357 (2010)

Lange, B.M.H.
Der virtuelle Patient - Systembiologie ist die Chance für die individuelle Medizin.
GENOMXPRESS, 1.10:6-8 (2010)

Scholz, A.-K., Klebl, B.M., Morkel, M., Lehrach, H., Dahl, A., Lange, B.M.H.
A flexible multi-well format for immunofluorescence screening microscopy of small molecule inhibitors.
ASSAY and Drug Development Technologies, 8:571-80 (2010)

Habermann, K., Lange, B.M.H.
Centrosomes: Methods for Preparation.
In: ENCYCLOPEDIA OF LIFE SCIENCES 2010, John Wiley & Sons, Ltd: Chichester (2010)

2009 .......

Hormeno, S., Ibarra, B., Chichón, F.J., Habermann, K., Lange, B.M.H.,
Valpuesta, J.M., Carrascosa, J.L. and Arias-Gonzalez, J.R.
Single centrosome manipulation reveals its electric charge and associated dynamic structure.
Biophys J., 97(4):1022-30 (2009)

Fogeron, M.-L., Müller, H., Lehmann, V., Habermann, K., Kurtz, T.
Scholz, A.-K., Siebert, S., Rak, K.-H., Gobom, J. and Lange B.M.H.
Protein Complex Composition and Function in Health and Disease.
Science Inside, 2:66-67 (2007)

Varmark, H., Llamazares, S., Rebollo, E., Lange, B.M.H., Reina, J., Schwarz, H. and Gonzalez, C.
Asterless Is a Centriolar Protein Required for Centrosome Function and Embryo Development in Drosophila.
Current Biology ; 17(20):1735-1745 (2007)

Müller, H., Fogeron, M.-L., Lehmann, V. and Lange, B.M.H.
Das andere Ende des Spindelcheckpoints.
Biospektrum, 13: 32-34 (2007)

Müller, H., Fogeron, M.-L., Lehmann, V., Lehrach, H. and Lange, B.M.H.
A Centrosome-Independent Role for γ-TuRC Proteins in the Spindle Assembly Checkpoint.
Science, 314: 654-656 (2006)

Lehmann, V.; Müller, H. and Lange, B.M.H.
Immunoisolation of centrosomes from Drosophila melanogaster.
Current Protocols in Cell Biology, Supplement 29, 3.17.1-3.17.13. (2006)

Lange, B.M.H., Kirfel, G., Gestmann, I., Herzog, V. and González, C.
Structure and Microtubule-Nucleation Activity of Isolated Drosophila Embryo Centrosomes Characterized by Whole Mount Scanning and Transmission Electron Microscopy.
Histochemistry and Cell Biology, 124(3-4):325-34 (2005)

Sauer, S., Lange, B. M. H., Gobom, J., Nyarsik, L., Seitz, H. and Lehrach, H.
Miniaturization in functional genomics and proteomics.
Nature Reviews Genetics, 6(6):465-476 (2005)

Ebert, M.P., Kruger, S., Fogeron, M.-L., Lamer, S., Chen, J., Pross, M., Schulz, H.U., Lage, H., Heim, S., Roessner, A., Malfertheiner, P. and Rocken, C.
Overexpression of cathepsin B in gastric cancer identified by proteome analysis.
Proteomics; 5(6):1693-704 (2005)

Lange, B.M.H., Rebollo, E., Herold and A. Gonzalez, C.
Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes.
EMBO Journal, 21:5364-5374 (2002)

Lange, B.M.H.
Integration of the centrosome in cell cycle control, stress response and signal transduction pathways.
Current Opinion in Cell Biology, 14:35-43 (2002)

Mollinari C, Lange B.M.H. and Gonzalez C.
Miranda, a protein involved in neuroblast asymmetric division, is associated with embryonic centrosomes of Drosophila melanogaster.
Biololgy of the Cell, 94(1): 1-13 (2002)
  
Lange, B.M.H., Faragher, A.J., March, P. and Gull, K.
Centriole duplication and maturation in animal cells.
Current Topics in Developmental Biology, 49:235-249 (2000)    

Lange, B.M.H, Bachi, A., Wilm, M. and González, C.
Hsp90 is a core centrosomal component and is required at different stages of the centrosome cycle in Drosophila and vertebrates.
EMBO Journal 19(6):1252-1262 (2000)

Lange, B. M. H. and Gull, K.
Structure and function of the centriole in animal cells - progress and questions.
Trends in Cell Biology, 6:348-352 (1996)

Lange, B.M.H. and Gull, K.
A structural study of isolated mammalian centrioles using negative staining electron microscopy.
Journal of Structural Biology, 117:222-226 (1996)

Lange, B.M.H. and Gull, K.
A molecular marker for centriole maturation in the mammalian cell cycle.
Journal of Cell Biology 130 (4):919-927 (1995)

Lange, B.M.H., Sherwin, T., Hagan, I.M. and Gull, K.
The basics of immunofluorescence video-microscopy for mammalian and microbial systems.  
Trends in Cell Biology, 5:328-332 (1995)

Byard, E.H. and Lange, B.M.H.
Tubulin and Microtubules.
Essays in Biochemistry, 26:13-25 (1991)

MacRae, T.H., Lange, B.M.H. and Gull, K.  
Production and characterisation of monoclonal antibodies to the mammalian sperm cytoskeleton.
Molecular Reproduction and Development, 25:384-392 (1990)


Reports


Lange, B.M.H. and Gonzalez, C.
Immunoisolation of centrosomes from Drosophila melanogaster  embryos. 
DynaLogue October 3:10-11 (2000)

Lange, B.M.H.
The centrosome in cell cycle and signal transduction pathways.
Zellbiologie Aktuell, 1:18-20 (2004)