Publications

Effects of EpCAM overexpression on human breast cancer cell lines.
Gostner JM, Fong D, Wrulich OA, Lehne F, Zitt M, Hermann M, Krobitsch S, Martowicz A, Gastl G, Spizzo G.
BMC Cancer. 2011 Jan 31;11(1):45. [Epub ahead of print]

Huntington's Disease: from Molecular Basis to Therapeutic Advances.
Krobitsch S, Kazantsev AG.
Int J Biochem Cell Biol. 2011 Jan;43(1):20-4.

The KRAB-containing zinc-finger transcriptional regulator ZBRK1 activates SCA2 gene transcription through direct interaction with its gene product, ataxin-2.
Hallen L, Klein H, Stoschek C, Wehrmeyer S, Nonhoff U, Ralser M, Wilde J, Röhr C, Schweiger MR, Zatloukal K, Vingron M, Lehrach H, Konthur Z, Krobitsch S
Hum Mol Genet. 2011 Jan 1;20(1):104-14.

The effect of micrococcal nuclease digestion on nucleosome positioning data.
Chung HR, Dunkel I, Heise F, Linke C, Krobitsch S, Ehrenhofer-Murray AE, Sperling SR, Vingron M.
PLoS One. 2010 Dec 29;5(12):e15754.

Minimum information about a protein affinity reagent (MIAPAR).
Bourbeillon J, Orchard S, Benhar I, Borrebaeck C, de Daruvar A, Dübel S, Frank R, Gibson F, Gloriam D, Haslam N, Hiltker T, Humphrey-Smith I, Hust M, Juncker D, Koegl M, Konthur Z, Korn B, Krobitsch S, Muyldermans S, Nygren PA, Palcy S, Polic B, Rodriguez H, Sawyer A, Schlapshy M, Snyder M, Stoevesandt O, Taussig MJ, Templin M, Uhlen M, van der Maarel S, Wingren C, Hermjakob H, Sherman D.
Nat Biotechnol. 2010 Jul;28(7):650-3.

Transcriptome analysis by strand-specific sequencing of complementary DNA.
Parkhomchuk D, Borodina T, Amstislavskiy V, Banaru M, Hallen L, Krobitsch S, Lehrach H, Soldatov A.
Nucleic Acids Res. 2009 Oct;37(18)

A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth
Ralser M, Wamelink MM, Struys EA, Joppich C, Krobitsch S, Jakobs C, Lehrach H.
Proc Natl Acad Sci U S A. 2008 Nov 18

Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans
Markus Ralser, Almut Nebel, Rabea Kleindorp, Sylvia Krobitsch, Hans Lehrach, Stefan Schreiber, Richard Reinhardt and Bernd Timmermann
BMC Genetics 2008 May; 9:38

Dynamic re-routing of the carbohydrate flux is key to counteracting oxidative stress
Ralser, M., Wamelink, M.M., Kowald, A., Gerisch, B., Heeren, G., Klipp, E., Struys, E.A., Klipp, E., Jakobs, C., Breitenbach, M., Lehrach, H., and Krobitsch, S.
Journal of Biology 2007 Dec; 6:10: 1-18.

Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.
Nonhoff U, Ralser M, Welzel F, Piccini I, Balzereit D, Yaspo ML, Lehrach H, Krobitsch S.
Mol Biol Cell. 2007 Apr;18(4):1385-96.

ProteomeBinders: planning a European resource of affinity
reagents for analysis of the human proteome.
Taussig MJ, Stoevesandt O, Borrebaeck CA, Bradbury AR, Cahill D, Cambillau C, de Daruvar A, Dubel S, Eichler J, Frank R, Gibson TJ, Gloriam D, Gold L, Herberg FW, Hermjakob H, Hoheisel JD, Joos TO, Kallioniemi O, Koegl M, Konthur Z, Korn B, Kremmer E, Krobitsch S, Landegren U, van der Maarel S, McCafferty J, Muyldermans S, Nygren PA, Palcy S, Pluckthun A, Polic B, Przybylski M, Saviranta P, Sawyer A, Sherman DJ, Skerra A, Templin M, Ueffing M, Uhlen M.
Nat Methods. 2007 Jan;4(1):13-7

Triose Phosphate Isomerase Deficiency is caused by altered dimerization  - not catalytic inactivity - of the mutant enzymes.
Ralser, M., Heeren, G., Breitenbach, M., Lehrach, H., and Krobitsch, S.
PlosOne 2006 Dec 20;1:e30.

An efficient and economic enhancer mix for PCR.
Ralser M, Querfurth R, Warnatz HJ, Lehrach H, Yaspo ML, Krobitsch S
Biochem Biophys Res Commun. 2006 Sep 1;347(3):747-51.

A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksoz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE.
Cell. 2005 Sep 23;122(6):957-68.

Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.
Ralser M, Nonhoff U, Albrecht M, Lengauer T, Wanker EE, Lehrach H, Krobitsch S.
Hum Mol Genet. 2005 Oct 1;14(19):2893-2909.

Generation of a yeast two-hybrid strain suitable for competitive protein binding analysis.
Ralser M, Goehler H, Wanker EE, Lehrach H, Krobitsch S.
Biotechniques. 2005 Aug;39(2):165-6, 168.

An integrative approach to gain insights into the cellular function of human ataxin-2.
Ralser M, Albrecht M, Nonhoff U, Lengauer T, Lehrach H, Krobitsch S.
J Mol Biol. 2005 Feb 11;346(1):203-14.

Heat shock protein 100 and the amastigote stage-specific A2 proteins of Leishmania donovani.
Clos J, Klaholz L, Kroemer M, Krobitsch S, Lindquist S.
Med Microbiol Immunol (Berl). 2001 Nov;190(1-2):47-50.

Investigating protein conformation-based inheritance and disease in yeast.
Lindquist S, Krobitsch S, Li L, Sondheimer N.
Philos Trans R Soc Lond B Biol Sci. 2001 Feb 28;356(1406):169-76.

Cross-species homologous recombination in Leishmania donovani reveals the sites of integration.
Krobitsch S, Clos J.
Mol Biochem Parasitol. 2000 Mar 15;107(1):123-8.

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins.
Krobitsch S, Lindquist S.
Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1589-94.

Heat shock as a regular feature of the life cycle of Leishmania parasites.
Clos J, Krobitsch S.
American Zoologist 1999 39: 848-856.

A novel role for 100 kD heat shock proteins in the parasite Leishmania donovani.
Krobitsch S, Clos J.
Cell Stress Chaperones. 1999 Sep;4(3):191-8.

Leishmania donovani heat shock protein 100. Characterization and function in amastigote stage differentiation.
Krobitsch S, Brandau S, Hoyer C, Schmetz C, Hubel A, Clos J.
J Biol Chem. 1998 Mar 13;273(11):6488-94.

Leishmania major Hsp100 is required chiefly in the mammalian stage of the parasite.
Hubel A, Krobitsch S, Horauf A, Clos J.
Mol Cell Biol. 1997 Oct;17(10):5987-95.

Interaction with the recombination hot spot chi in vivo converts the RecBCD enzyme of Escherichia coli into a chi-independent recombinase by inactivation of the RecD subunit.
Koppen A, Krobitsch S, Thoms B, Wackernagel W.
Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6249-53.