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Barnett Newman, Who's Afraid of Red,
Yellow and Blue IV 1969-70, Stiftung Preussischer Kulturbesitz, Berlin
The sensory experience of this painting evoked in some an
unbearable perhaps painful condition, which resulted
repeatedly in altered CNS response such as
vandalism |
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Sensitization
toward physical stimulation as well as
chronic pain constitutes a widespread medical problem. New approaches
especially for interference with pain are urgently needed. We focus on
the elucidation of intracellular signaling events underlying
sensitization. Knowledge about this aspect is especially sparse.
Increasingly,
genetic mutations are identified, which underly
inherited mental retardation. The functional implications of the
mutation for the
protein, its interactors, and the connected signaling network have to
be investigated. Thereby the gap between phenotype and genotype can be
filled and basic mechanism of the brain can be understood.
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Human Molecular Genetics
