Publications

Mutzel, V.; Schwämmle, T.; Oeverdieck, S.; Librenjak, L.; Boesen, B.; Bothe, M.; Gjaltema, R. A. F.; Dunkel, I.; Noviello, G.; Schulz, E. G.: Antisense transcription can induce expression memory via stable promoter repression. (2024)

MPG.PuRe

DOI

pre-print

Schulz EG.

BREACHing new grounds in fragile X syndrome: Trinucleotide expansion linked to genome-wide heterochromatin domains and genome misfolding

Molecular Cell (2024), 84(3), 413-414

DOI

Ravid Lustig L., Sampath Kumar A., Schwämmle T., Dunkel I., Noviello G., Limberg E., Weigert R., Pacini G., Buschow R., Ghauri A., Stötzel M., Wittler L., Meissner A., Schulz EG.

GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers

Nature Cell Biology (2023), 25(11):1704-1715.

DOI

Agostinho de Sousa J, Wong C-W, Dunkel I, Owens T, Voigt P, Hodgson A, Baker D, Schulz EG, Reik W, Smith A, Rostovskaya M, von Meyenn F.

Epigenetic dynamics during capacitation of naïve human pluripotent stem cells.

Science Advances (2023), 9(39): eadg1936.

DOI

Sultana Z, Dorel M, Klinger B, Sieber A, Dunkel I, Blüthgen N, Schulz EG.

Modeling unveils sex differences of signaling networks in mouse embryonic stem cells.

Molecular Systems Biology (2023), e11510.

DOI

Noviello G, Gjaltema RAF, Schulz EG.

CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression.

Nature Communications (2023), 14(1): 3225.

DOI

Iyer, D. P., van der Weijden, V. A., Khoei, H. H., McCarthy, A., Rayon, T., Simon, C. S., Dunkel, I., Wamaitha, S. E., Elder, K., Snell, P., Christie, L., Schulz, E. G., Niakan, K. K., Rivron, N., & Bulut-Karslioglu, A.

Delay of human early development via in vitro diapause.

BioRxiv (2023)

DOI

Noviello G, Gjaltema RAF, Schulz EG.

CasTuner: a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression.

BioRxiv (2022)

DOI

Ravid Lustig L, Sampath Kumar A, Schwämmle T, Dunkel I, Noviello G, Weigert R, Pacini G, Buschow R, Ghauri A, Stoetzel M, Wittler L, Meissner A, Schulz EG.

GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of a distal enhancer element.

BioRxiv (2022)

DOI

Gjaltema RAF*, Schwämmle T*, Kautz P, Robson M, Schöpflin R, Lustig LR, Brandenburg L, Dunkel I, Vechiatto C, Ntini E, Mutzel V, Schmiedel V, Marsico A, Mundlos S, Schulz EG.

Distal and proximal cis-regulatory elements sense X-chromosomal dosage and developmental state at the Xist locus.

Molecular Cell (2022) 82, 190-208

Source

Genolet O, Ravid Lustig L and Schulz EG.

Dissecting molecular phenotypes through FACS-based pooled CRISPR screens.

Methods Mol Biol. (2022)

DOI

Pacini, G, Dunkel, I, Mages, N, Mutzel, V, Timmermann, B, Marsico, A, and Schulz, E G.

Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution

Nature Communications 2021, 12.1, 1–17.

Source

DOI

Genolet, O, Monaco, A A, Dunkel, I, Boettcher, M, and Schulz, E G.

Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach

Genome Biology 2021, 22

Source

DOI

Gjaltema, R A, Schwämmle, T, Kautz, P, Robson, M, Schöpflin, R, Lustig, L R, Brandenburg, L, Dunkel, I, Vechiatto, C, Ntini, E, Mutzel, V, Schmiedel, V, Marsico, A, Mundlos, S, and Schulz, E G.

Distal and proximal cis-regulatory elements sense X-chromosomal dosage and developmental state at the Xist locus

BioRxiv, 2021

Source

Mutzel V &Schulz EG.

Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation.

BioEssays 2020 Apr;42(4):e1900163

Source

DOI

Barros de Andrade E Sousa L, Jonkers I, Syx L, Dunkel I, Chaumeil J, Picard C, Foret B, Chen CJ, Lis JT, Heard E, Schulz EG, Marsico A.

Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features.

Genome Res. 2019 Jun 7. pii: gr.245027.118. [Epub ahead of print]

Source

DOI

Mutzel V, Okamoto I, Dunkel I, Saitou M, Giorgetti L, Heard E, Schulz EG

A symmetric toggle switch explains the onset of random X inactivation in different mammals.

Nature Structural and Molecular Biology 2019 May;26(5):350-360. Epub 2019 Apr 8.

Source

DOI

Barros de Anrade e Sousa L, Jonkers I, Syx L, Chaumeil J, Picard C, Foret B, Chen C, Lis JT, Heard E, Schulz EG, Marsico A

Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features.

BioRxiv 2019

DOI

Gjaltema RAF, Schulz EG

CRISPR/dCas9 switch systems for temporal transcriptional control

Methods in Molecular Biology, 2018, 1767:167-185

Mutzel V, Okamoto I, Dunkel I, Saitou M, Giorgetti L, Heard E, Schulz EG

Two coupled feedback loops explain random mono-allelic Xist upregulation at the onset of X-chromosome inactivation

BioRxiv, 2017, doi: https://doi.org/10.1101/204909

Source

DOI

Schulz EG

X-chromosome dosage as a modulator of pluripotency, signalling and differentiation?

Philosophical Transactions of the Royal Society B: Biological Sciences, 2017, 372.1733, 20160366

Zhan Y, Mariani L, Barozzi I, Schulz EG, Blüthgen N, Stadler M, Tiana G, Giorgetti L

Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes.

Genome Reseach, 2017 Mar;27(3):479-490

Source

Schulz EG, Meisig J, Nakamura T, Okamoto I, Sieber A, Picard C, Borensztein M, Saitou M, Blüthgen N, Heard E

The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network

Cell Stem Cell, 2014, 14:203-216

Schulz EG, Heard E

Role and control of X chromosome dosage in mammalian development

Current Opinion in Genetics & Development, 2013, 23(2): 109-115

Nora EP, Lajoie BR*, Schulz EG*, Giorgetti L*, Okamoto I, Servant N, Piolot T, van Berkum NL, Meisig J, Sedat J, Gribnau J, Barillot E, Blüthgen N, Dekker J# and Heard E#

Spatial partitioning of the regulatory landscape of the X-inactivation centre

Nature, 2012, 485(7398):381-5

Schulz EG, Nora EP, Heard E

Rnf12 – A Jack of All Trades in X Inactivation

PLoS Genetics, 2011, 7(1): e1002002

Schulz EG, Mariani L, Radbruch A and Höfer T

Sequential polarization and imprinting of type 1 T-helper lymphocytes by interferon-γ and interleukin-12

IMMUNITY, 2009, 30 (5), 673-683